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Epigenetic silencing by the SMC5/6 complex mediates HIV-1 latency

After viral entry and reverse transcription, HIV-1 proviruses that fail to integrate are epigenetically silenced, but the underlying mechanism has remained unclear. Using a genome-wide CRISPR/Cas9 knockout screen, we identified the host SMC5/6 complex as essential for this epigenetic silencing. We s...

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Detalles Bibliográficos
Autores principales:	Irwan, Ishak D., Bogerd, Hal P., Cullen, Bryan R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712108/ https://www.ncbi.nlm.nih.gov/pubmed/36376394 http://dx.doi.org/10.1038/s41564-022-01264-z

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