Broad-spectrum CRISPR-Cas13a enables efficient phage genome editing

CRISPR-Cas13 proteins are RNA-guided RNA nucleases that defend against incoming RNA and DNA phages by binding to complementary target phage transcripts followed by general, non-specific RNA degradation. Here we analysed the defensive capabilities of LbuCas13a from Leptotrichia buccalis and found it...

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Detalles Bibliográficos
Autores principales: Adler, Benjamin A., Hessler, Tomas, Cress, Brady F., Lahiri, Arushi, Mutalik, Vivek K., Barrangou, Rodolphe, Banfield, Jillian, Doudna, Jennifer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712115/
https://www.ncbi.nlm.nih.gov/pubmed/36316451
http://dx.doi.org/10.1038/s41564-022-01258-x

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