Glycan Modulation of Insulin‐like Growth Factor‐1 Receptor

The insulin‐like growth factor‐1 receptor (IGF‐1R) is a receptor tyrosine kinase (RTK) that plays critical roles in cancer. Microarray, computational, thermodynamic, and cellular imaging studies reveal that activation of IGF‐1R by its cognate ligand IGF1 is inhibited by shorter, soluble heparan sulf...

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Detalles Bibliográficos
Autores principales: Boothello, Rio S., Sankaranarayanan, Nehru Viji, Sistla, Jyothi C., Nagarajan, Balaji, Sharon, Chetna, Chittum, John E., Niyaz, Rabiya Y., Roy, Swarnali, Nandi, Aditi, O'Hara, Connor P., Gangji, Rahaman Navaz, Afosah, Daniel K., Ongolu, Ravikumar, Patel, Bhaumik B., Desai, Umesh R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712175/
https://www.ncbi.nlm.nih.gov/pubmed/36205924
http://dx.doi.org/10.1002/anie.202211320

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