The cytoprotective role of GM1 ganglioside in Huntington disease cells

BACKGROUND: Huntington disease (HD) is a neurodegenerative disease where a genetic mutation leads to excessive polyglutamine (Q) repeats in the huntingtin protein. The polyglutamine repeats create toxic plaques when the protein is cleaved, leading to neuron death. The glycolipid GM1 ganglioside (GM1...

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Detalles Bibliográficos
Autores principales: Hart, Hannah S., Valentin, Madeline A., Peters, Stephanie Toering, Holler, Susan W., Wang, Hongmin, Harmon, Aaron F., Holler, Larry D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712292/
https://www.ncbi.nlm.nih.gov/pubmed/36180805
http://dx.doi.org/10.1007/s11033-022-07830-2

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