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Brain gyrification in bipolar disorder: a systematic review of neuroimaging studies

Bipolar disorder (BD) is a severe mental illness with a strong genetic component. Genetic variations have been involved in the risk of this disorder, including those mediating brain function and neurodevelopment. Early neurodevelopment and neuroprogression processes could be reflected in brain gyrif...

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Autores principales: Miola, Alessandro, Cattarinussi, Giulia, Loré, Maria Lavinia, Ghiotto, Niccolò, Collantoni, Enrico, Sambataro, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712346/
https://www.ncbi.nlm.nih.gov/pubmed/36042153
http://dx.doi.org/10.1007/s11682-022-00713-x
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author Miola, Alessandro
Cattarinussi, Giulia
Loré, Maria Lavinia
Ghiotto, Niccolò
Collantoni, Enrico
Sambataro, Fabio
author_facet Miola, Alessandro
Cattarinussi, Giulia
Loré, Maria Lavinia
Ghiotto, Niccolò
Collantoni, Enrico
Sambataro, Fabio
author_sort Miola, Alessandro
collection PubMed
description Bipolar disorder (BD) is a severe mental illness with a strong genetic component. Genetic variations have been involved in the risk of this disorder, including those mediating brain function and neurodevelopment. Early neurodevelopment and neuroprogression processes could be reflected in brain gyrification patterns and help optimize the prediction and diagnosis of such disorders that is often delayed. Previous neuroimaging studies using this measure in patients with bipolar disorder revealed controversial results. This systematic review aimed to summarize available neuroimaging investigations on gyrification in BD compared to healthy controls (HC) and/or other psychiatric groups. Fourteen studies including 733 patients with BD, 585 patients with schizophrenia (SCZ), 90 with schizoaffective disorder (SZA), and 1380 healthy subjects were identified. Overall, a heterogeneous pattern of gyrification emerged between patients with BD and HC. Interestingly, increased gyrification or no differences were also observed in patients with BD compared to those with the schizophrenia-spectrum disorders. Furthermore, relatives of patients with BD showed lower or no differences in gyrification compared to healthy subjects without a family history of affective illness. Differences in the design and in methodological approaches could have contributed to the heterogeneity of the findings. The current review supports an altered brain gyrification pattern that underlies the pathophysiology of BD spanning large anatomical and functional neural networks, associated with altered cognitive functioning, difficulties in processing and affective regulation, and clinical symptoms. Longitudinal studies are needed to test different bipolar phenotypes and pharmacological effects on gyrification. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11682-022-00713-x.
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spelling pubmed-97123462022-12-02 Brain gyrification in bipolar disorder: a systematic review of neuroimaging studies Miola, Alessandro Cattarinussi, Giulia Loré, Maria Lavinia Ghiotto, Niccolò Collantoni, Enrico Sambataro, Fabio Brain Imaging Behav Review Article Bipolar disorder (BD) is a severe mental illness with a strong genetic component. Genetic variations have been involved in the risk of this disorder, including those mediating brain function and neurodevelopment. Early neurodevelopment and neuroprogression processes could be reflected in brain gyrification patterns and help optimize the prediction and diagnosis of such disorders that is often delayed. Previous neuroimaging studies using this measure in patients with bipolar disorder revealed controversial results. This systematic review aimed to summarize available neuroimaging investigations on gyrification in BD compared to healthy controls (HC) and/or other psychiatric groups. Fourteen studies including 733 patients with BD, 585 patients with schizophrenia (SCZ), 90 with schizoaffective disorder (SZA), and 1380 healthy subjects were identified. Overall, a heterogeneous pattern of gyrification emerged between patients with BD and HC. Interestingly, increased gyrification or no differences were also observed in patients with BD compared to those with the schizophrenia-spectrum disorders. Furthermore, relatives of patients with BD showed lower or no differences in gyrification compared to healthy subjects without a family history of affective illness. Differences in the design and in methodological approaches could have contributed to the heterogeneity of the findings. The current review supports an altered brain gyrification pattern that underlies the pathophysiology of BD spanning large anatomical and functional neural networks, associated with altered cognitive functioning, difficulties in processing and affective regulation, and clinical symptoms. Longitudinal studies are needed to test different bipolar phenotypes and pharmacological effects on gyrification. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11682-022-00713-x. Springer US 2022-08-31 2022 /pmc/articles/PMC9712346/ /pubmed/36042153 http://dx.doi.org/10.1007/s11682-022-00713-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Miola, Alessandro
Cattarinussi, Giulia
Loré, Maria Lavinia
Ghiotto, Niccolò
Collantoni, Enrico
Sambataro, Fabio
Brain gyrification in bipolar disorder: a systematic review of neuroimaging studies
title Brain gyrification in bipolar disorder: a systematic review of neuroimaging studies
title_full Brain gyrification in bipolar disorder: a systematic review of neuroimaging studies
title_fullStr Brain gyrification in bipolar disorder: a systematic review of neuroimaging studies
title_full_unstemmed Brain gyrification in bipolar disorder: a systematic review of neuroimaging studies
title_short Brain gyrification in bipolar disorder: a systematic review of neuroimaging studies
title_sort brain gyrification in bipolar disorder: a systematic review of neuroimaging studies
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712346/
https://www.ncbi.nlm.nih.gov/pubmed/36042153
http://dx.doi.org/10.1007/s11682-022-00713-x
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