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Investigation of native and aggregated therapeutic proteins in human plasma with asymmetrical flow field-flow fractionation and mass spectrometry

Physiochemical degradation of therapeutic proteins in vivo during plasma circulation after administration can have a detrimental effect on their efficacy and safety profile. During drug product development, in vivo animal studies are necessary to explore in vivo protein behaviour. However, these stu...

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Detalles Bibliográficos
Autores principales:	Ramm, Ingrid, Leeman, Mats, Schagerlöf, Herje, León, Ileana Rodríguez, Castro, Alejandra, Nilsson, Lars
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2022
Materias:	Paper in Forefront
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712356/ https://www.ncbi.nlm.nih.gov/pubmed/36198918 http://dx.doi.org/10.1007/s00216-022-04355-2

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