Cardiomyocyte-specific overexpression of syndecan-4 in mice results in activation of calcineurin-NFAT signalling and exacerbated cardiac hypertrophy

BACKGROUND: Cardiomyocyte hypertrophy is a hallmark of cardiac dysfunction in patients with aortic stenosis (AS), and can be triggered by left ventricular (LV) pressure overload in mice by aortic banding (AB). Syndecan-4 is a transmembrane heparan sulphate proteoglycan which is found increased in th...

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Detalles Bibliográficos
Autores principales: Lunde, Ida G., Aronsen, J. Magnus, Melleby, A. Olav, Strand, Mari E., Skogestad, Jonas, Bendiksen, Bård A., Ahmed, M. Shakil, Sjaastad, Ivar, Attramadal, Håvard, Carlson, Cathrine R., Christensen, Geir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712407/
https://www.ncbi.nlm.nih.gov/pubmed/36205855
http://dx.doi.org/10.1007/s11033-022-07985-y

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