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Metabolites extracted from microorganisms as potential inhibitors of glycosidases (α-glucosidase and α-amylase): A review
α-Glucosidase and α-amylase are the two main glycosidases that participate in the metabolism of carbohydrates. Inhibitors of these two enzymes are considered an important medical treatment for carbohydrate uptake disorders, such as diabetes and obesity. Microbes are an important source of constituen...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712454/ https://www.ncbi.nlm.nih.gov/pubmed/36466660 http://dx.doi.org/10.3389/fmicb.2022.1050869 |
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author | Wang, Xiaojing Li, Jiaying Shang, Jiaqi Bai, Jing Wu, Kai Liu, Jing Yang, Zhijun Ou, Hao Shao, Lei |
author_facet | Wang, Xiaojing Li, Jiaying Shang, Jiaqi Bai, Jing Wu, Kai Liu, Jing Yang, Zhijun Ou, Hao Shao, Lei |
author_sort | Wang, Xiaojing |
collection | PubMed |
description | α-Glucosidase and α-amylase are the two main glycosidases that participate in the metabolism of carbohydrates. Inhibitors of these two enzymes are considered an important medical treatment for carbohydrate uptake disorders, such as diabetes and obesity. Microbes are an important source of constituents that have the potential to inhibit glycosidases and can be used as sources of new drugs and dietary supplements. For example, the α-glucosidase inhibitor acarbose, isolated from Actinoplanes sp., has played an important role in adequately controlling type 2 diabetes, but this class of marketed drugs has many drawbacks, such as poor compliance with treatment and expense. This demonstrates the need for new microorganism-derived resources, as well as novel classes of drugs with better compliance, socioeconomic benefits, and safety. This review introduces the literature on microbial sources of α-glucosidase and α-amylase inhibitors, with a focus on endophytes and marine microorganisms, over the most recent 5 years. This paper also reviews the application of glycosidase inhibitors as drugs and dietary supplements. These studies will contribute to the future development of new microorganism-derived glycosidase inhibitors. |
format | Online Article Text |
id | pubmed-9712454 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97124542022-12-02 Metabolites extracted from microorganisms as potential inhibitors of glycosidases (α-glucosidase and α-amylase): A review Wang, Xiaojing Li, Jiaying Shang, Jiaqi Bai, Jing Wu, Kai Liu, Jing Yang, Zhijun Ou, Hao Shao, Lei Front Microbiol Microbiology α-Glucosidase and α-amylase are the two main glycosidases that participate in the metabolism of carbohydrates. Inhibitors of these two enzymes are considered an important medical treatment for carbohydrate uptake disorders, such as diabetes and obesity. Microbes are an important source of constituents that have the potential to inhibit glycosidases and can be used as sources of new drugs and dietary supplements. For example, the α-glucosidase inhibitor acarbose, isolated from Actinoplanes sp., has played an important role in adequately controlling type 2 diabetes, but this class of marketed drugs has many drawbacks, such as poor compliance with treatment and expense. This demonstrates the need for new microorganism-derived resources, as well as novel classes of drugs with better compliance, socioeconomic benefits, and safety. This review introduces the literature on microbial sources of α-glucosidase and α-amylase inhibitors, with a focus on endophytes and marine microorganisms, over the most recent 5 years. This paper also reviews the application of glycosidase inhibitors as drugs and dietary supplements. These studies will contribute to the future development of new microorganism-derived glycosidase inhibitors. Frontiers Media S.A. 2022-11-17 /pmc/articles/PMC9712454/ /pubmed/36466660 http://dx.doi.org/10.3389/fmicb.2022.1050869 Text en Copyright © 2022 Wang, Li, Shang, Bai, Wu, Liu, Yang, Ou and Shao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Wang, Xiaojing Li, Jiaying Shang, Jiaqi Bai, Jing Wu, Kai Liu, Jing Yang, Zhijun Ou, Hao Shao, Lei Metabolites extracted from microorganisms as potential inhibitors of glycosidases (α-glucosidase and α-amylase): A review |
title | Metabolites extracted from microorganisms as potential inhibitors of glycosidases (α-glucosidase and α-amylase): A review |
title_full | Metabolites extracted from microorganisms as potential inhibitors of glycosidases (α-glucosidase and α-amylase): A review |
title_fullStr | Metabolites extracted from microorganisms as potential inhibitors of glycosidases (α-glucosidase and α-amylase): A review |
title_full_unstemmed | Metabolites extracted from microorganisms as potential inhibitors of glycosidases (α-glucosidase and α-amylase): A review |
title_short | Metabolites extracted from microorganisms as potential inhibitors of glycosidases (α-glucosidase and α-amylase): A review |
title_sort | metabolites extracted from microorganisms as potential inhibitors of glycosidases (α-glucosidase and α-amylase): a review |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712454/ https://www.ncbi.nlm.nih.gov/pubmed/36466660 http://dx.doi.org/10.3389/fmicb.2022.1050869 |
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