Host-dependent resistance of Group A Streptococcus to sulfamethoxazole mediated by a horizontally-acquired reduced folate transporter

Described antimicrobial resistance mechanisms enable bacteria to avoid the direct effects of antibiotics and can be monitored by in vitro susceptibility testing and genetic methods. Here we describe a mechanism of sulfamethoxazole resistance that requires a host metabolite for activity. Using a comb...

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Detalles Bibliográficos
Autores principales: Rodrigo, M. Kalindu D., Saiganesh, Aarti, Hayes, Andrew J., Wilson, Alisha M., Anstey, Jack, Pickering, Janessa L., Iwasaki, Jua, Hillas, Jessica, Winslow, Scott, Woodman, Tabitha, Nitschke, Philipp, Lacey, Jake A., Breese, Karen J., van der Linden, Mark P. G., Giffard, Philip M., Tong, Steven Y. C., Gray, Nicola, Stubbs, Keith A., Carapetis, Jonathan R., Bowen, Asha C., Davies, Mark R., Barnett, Timothy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712650/
https://www.ncbi.nlm.nih.gov/pubmed/36450721
http://dx.doi.org/10.1038/s41467-022-34243-3

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