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DN200434, an orally available inverse agonist of estrogen-related receptor γ, induces ferroptosis in sorafenib-resistant hepatocellular carcinoma

Sorafenib, originally identified as an inhibitor of multiple oncogenic kinases, induces ferroptosis in hepatocellular carcinoma (HCC) cells. Several pathways that mitigate sorafenib-induced ferroptosis confer drug resistance; thus strategies that enhance ferroptosis increase sorafenib efficacy. Orph...

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Detalles Bibliográficos
Autores principales:	Kim, Dong-Ho, Kim, Mi-Jin, Kim, Na-Young, Lee, Seunghyeong, Byun, Jun-Kyu, Yun, Jae Won, Lee, Jaebon, Jin, Jonghwa, Kim, Jina, Chin, Jungwook, Cho, Sung Jin, Lee, In-Kyu, Choi, Yeon-Kyung, Park, Keun-Gyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Biochemistry and Molecular Biology 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712702/ https://www.ncbi.nlm.nih.gov/pubmed/36016501 http://dx.doi.org/10.5483/BMBRep.2022.55.11.089

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