Cargando…
The role of immunomodulatory metabolites in shaping the inflammatory response of macrophages
Macrophage activation has long been implicated in a myriad of human pathophysiology, particularly in the context of the dysregulated capacities of an unleashing intracellular or/and extracellular inflammatory response. A growing number of studies have functionally coupled the macrophages’ inflammato...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Biochemistry and Molecular Biology
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712705/ https://www.ncbi.nlm.nih.gov/pubmed/36195564 http://dx.doi.org/10.5483/BMBRep.2022.55.11.128 |
_version_ | 1784841846281732096 |
---|---|
author | Park, Doyoung Lim, Gyumin Yoon, Sung-Jin Yi, Hyon-Seung Choi, Dong Wook |
author_facet | Park, Doyoung Lim, Gyumin Yoon, Sung-Jin Yi, Hyon-Seung Choi, Dong Wook |
author_sort | Park, Doyoung |
collection | PubMed |
description | Macrophage activation has long been implicated in a myriad of human pathophysiology, particularly in the context of the dysregulated capacities of an unleashing intracellular or/and extracellular inflammatory response. A growing number of studies have functionally coupled the macrophages’ inflammatory capacities with dynamic metabolic reprogramming which occurs during activation, albeit the results have been mostly interpreted through classic metabolism point of view; macrophages take advantage of the rewired metabolism as a source of energy and for biosynthetic precursors. However, a specific subset of metabolic products, namely immune-modulatory metabolites, has recently emerged as significant regulatory signals which control inflammatory responses in macrophages and the relevant extracellular milieu. In this review, we introduce recently highlighted immuno-modulatory metabolites, with the aim of understanding their physiological and pathological relevance in the macrophage inflammatory response. |
format | Online Article Text |
id | pubmed-9712705 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Korean Society for Biochemistry and Molecular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-97127052022-12-08 The role of immunomodulatory metabolites in shaping the inflammatory response of macrophages Park, Doyoung Lim, Gyumin Yoon, Sung-Jin Yi, Hyon-Seung Choi, Dong Wook BMB Rep Invited Mini Review Macrophage activation has long been implicated in a myriad of human pathophysiology, particularly in the context of the dysregulated capacities of an unleashing intracellular or/and extracellular inflammatory response. A growing number of studies have functionally coupled the macrophages’ inflammatory capacities with dynamic metabolic reprogramming which occurs during activation, albeit the results have been mostly interpreted through classic metabolism point of view; macrophages take advantage of the rewired metabolism as a source of energy and for biosynthetic precursors. However, a specific subset of metabolic products, namely immune-modulatory metabolites, has recently emerged as significant regulatory signals which control inflammatory responses in macrophages and the relevant extracellular milieu. In this review, we introduce recently highlighted immuno-modulatory metabolites, with the aim of understanding their physiological and pathological relevance in the macrophage inflammatory response. Korean Society for Biochemistry and Molecular Biology 2022-11-30 2022-11-30 /pmc/articles/PMC9712705/ /pubmed/36195564 http://dx.doi.org/10.5483/BMBRep.2022.55.11.128 Text en Copyright © 2022 by the The Korean Society for Biochemistry and Molecular Biology https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Invited Mini Review Park, Doyoung Lim, Gyumin Yoon, Sung-Jin Yi, Hyon-Seung Choi, Dong Wook The role of immunomodulatory metabolites in shaping the inflammatory response of macrophages |
title | The role of immunomodulatory metabolites in shaping the inflammatory response of macrophages |
title_full | The role of immunomodulatory metabolites in shaping the inflammatory response of macrophages |
title_fullStr | The role of immunomodulatory metabolites in shaping the inflammatory response of macrophages |
title_full_unstemmed | The role of immunomodulatory metabolites in shaping the inflammatory response of macrophages |
title_short | The role of immunomodulatory metabolites in shaping the inflammatory response of macrophages |
title_sort | role of immunomodulatory metabolites in shaping the inflammatory response of macrophages |
topic | Invited Mini Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712705/ https://www.ncbi.nlm.nih.gov/pubmed/36195564 http://dx.doi.org/10.5483/BMBRep.2022.55.11.128 |
work_keys_str_mv | AT parkdoyoung theroleofimmunomodulatorymetabolitesinshapingtheinflammatoryresponseofmacrophages AT limgyumin theroleofimmunomodulatorymetabolitesinshapingtheinflammatoryresponseofmacrophages AT yoonsungjin theroleofimmunomodulatorymetabolitesinshapingtheinflammatoryresponseofmacrophages AT yihyonseung theroleofimmunomodulatorymetabolitesinshapingtheinflammatoryresponseofmacrophages AT choidongwook theroleofimmunomodulatorymetabolitesinshapingtheinflammatoryresponseofmacrophages AT parkdoyoung roleofimmunomodulatorymetabolitesinshapingtheinflammatoryresponseofmacrophages AT limgyumin roleofimmunomodulatorymetabolitesinshapingtheinflammatoryresponseofmacrophages AT yoonsungjin roleofimmunomodulatorymetabolitesinshapingtheinflammatoryresponseofmacrophages AT yihyonseung roleofimmunomodulatorymetabolitesinshapingtheinflammatoryresponseofmacrophages AT choidongwook roleofimmunomodulatorymetabolitesinshapingtheinflammatoryresponseofmacrophages |