Early T-bet promotes LFA1 upregulation required for CD8(+) effector and memory T cell development

The T-box transcription factor T-bet is regarded as a “master regulator” of CD4(+) Th1 differentiation and IFN-γ production. However, in multiple models of infection, T-bet appears less critical for CD8(+) T cell expansion and effector function. Here, we show that following vaccination with a replic...

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Detalles Bibliográficos
Autores principales: Pritchard, Gretchen Harms, Phan, Anthony T., Christian, David A., Blain, Trevor J., Fang, Qun, Johnson, John, Roy, Nathan H., Shallberg, Lindsey, Kedl, Ross M., Hunter, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712775/
https://www.ncbi.nlm.nih.gov/pubmed/36445307
http://dx.doi.org/10.1084/jem.20191287

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