Roles of circular RNAs in the pathogenesis and treatment of pancreatic cancer

Circular RNAs are single-stranded RNAs with a covalently closed structure formed by the process of back-splicing. Aberrant expression of circular RNAs contributes to the pathogenesis of a wide range of cancers. Pancreatic cancer is one of the most lethal cancers due to diagnostic difficulties and li...

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Autores principales: Seimiya, Takahiro, Otsuka, Motoyuki, Fujishiro, Mitsuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712786/
https://www.ncbi.nlm.nih.gov/pubmed/36467402
http://dx.doi.org/10.3389/fcell.2022.1023332
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author Seimiya, Takahiro
Otsuka, Motoyuki
Fujishiro, Mitsuhiro
author_facet Seimiya, Takahiro
Otsuka, Motoyuki
Fujishiro, Mitsuhiro
author_sort Seimiya, Takahiro
collection PubMed
description Circular RNAs are single-stranded RNAs with a covalently closed structure formed by the process of back-splicing. Aberrant expression of circular RNAs contributes to the pathogenesis of a wide range of cancers. Pancreatic cancer is one of the most lethal cancers due to diagnostic difficulties and limited therapeutic options. Circular RNAs are emerging as novel diagnostic biomarkers and therapeutic targets for pancreatic cancer. Moreover, recent advances in the therapeutic application of engineered circular RNAs have provided a promising approach to overcoming pancreatic cancer. This review discusses the roles of circular RNAs in the pathogenesis of pancreatic cancer and in potential treatment applications and their usefulness as diagnostic biomarkers.
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spelling pubmed-97127862022-12-02 Roles of circular RNAs in the pathogenesis and treatment of pancreatic cancer Seimiya, Takahiro Otsuka, Motoyuki Fujishiro, Mitsuhiro Front Cell Dev Biol Cell and Developmental Biology Circular RNAs are single-stranded RNAs with a covalently closed structure formed by the process of back-splicing. Aberrant expression of circular RNAs contributes to the pathogenesis of a wide range of cancers. Pancreatic cancer is one of the most lethal cancers due to diagnostic difficulties and limited therapeutic options. Circular RNAs are emerging as novel diagnostic biomarkers and therapeutic targets for pancreatic cancer. Moreover, recent advances in the therapeutic application of engineered circular RNAs have provided a promising approach to overcoming pancreatic cancer. This review discusses the roles of circular RNAs in the pathogenesis of pancreatic cancer and in potential treatment applications and their usefulness as diagnostic biomarkers. Frontiers Media S.A. 2022-11-17 /pmc/articles/PMC9712786/ /pubmed/36467402 http://dx.doi.org/10.3389/fcell.2022.1023332 Text en Copyright © 2022 Seimiya, Otsuka and Fujishiro. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Seimiya, Takahiro
Otsuka, Motoyuki
Fujishiro, Mitsuhiro
Roles of circular RNAs in the pathogenesis and treatment of pancreatic cancer
title Roles of circular RNAs in the pathogenesis and treatment of pancreatic cancer
title_full Roles of circular RNAs in the pathogenesis and treatment of pancreatic cancer
title_fullStr Roles of circular RNAs in the pathogenesis and treatment of pancreatic cancer
title_full_unstemmed Roles of circular RNAs in the pathogenesis and treatment of pancreatic cancer
title_short Roles of circular RNAs in the pathogenesis and treatment of pancreatic cancer
title_sort roles of circular rnas in the pathogenesis and treatment of pancreatic cancer
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712786/
https://www.ncbi.nlm.nih.gov/pubmed/36467402
http://dx.doi.org/10.3389/fcell.2022.1023332
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