Cargando…

Glutamine metabolism and radiosensitivity: Beyond the Warburg effect

Mounting data suggest that cancer cell metabolism can be utilized therapeutically to halt cell proliferation, metastasis and disease progression. Radiation therapy is a critical component of cancer treatment in curative and palliative settings. The use of metabolism-based therapeutics has become inc...

Descripción completa

Detalles Bibliográficos
Autores principales: Alden, Ryan S., Kamran, Mohammad Zahid, Bashjawish, Bassel A., Simone, Brittany A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712788/
https://www.ncbi.nlm.nih.gov/pubmed/36465373
http://dx.doi.org/10.3389/fonc.2022.1070514
_version_ 1784841865930997760
author Alden, Ryan S.
Kamran, Mohammad Zahid
Bashjawish, Bassel A.
Simone, Brittany A.
author_facet Alden, Ryan S.
Kamran, Mohammad Zahid
Bashjawish, Bassel A.
Simone, Brittany A.
author_sort Alden, Ryan S.
collection PubMed
description Mounting data suggest that cancer cell metabolism can be utilized therapeutically to halt cell proliferation, metastasis and disease progression. Radiation therapy is a critical component of cancer treatment in curative and palliative settings. The use of metabolism-based therapeutics has become increasingly popular in combination with radiotherapy to overcome radioresistance. Over the past year, a focus on glutamine metabolism in the setting of cancer therapy has emerged. In this mini-review, we discuss several important ways (DNA damage repair, oxidative stress, epigenetic modification and immune modulation) glutamine metabolism drives cancer growth and progression, and present data that inhibition of glutamine utilization can lead to radiosensitization in preclinical models. Future research is needed in the clinical realm to determine whether glutamine antagonism is a feasible synergistic therapy that can be combined with radiotherapy.
format Online
Article
Text
id pubmed-9712788
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-97127882022-12-02 Glutamine metabolism and radiosensitivity: Beyond the Warburg effect Alden, Ryan S. Kamran, Mohammad Zahid Bashjawish, Bassel A. Simone, Brittany A. Front Oncol Oncology Mounting data suggest that cancer cell metabolism can be utilized therapeutically to halt cell proliferation, metastasis and disease progression. Radiation therapy is a critical component of cancer treatment in curative and palliative settings. The use of metabolism-based therapeutics has become increasingly popular in combination with radiotherapy to overcome radioresistance. Over the past year, a focus on glutamine metabolism in the setting of cancer therapy has emerged. In this mini-review, we discuss several important ways (DNA damage repair, oxidative stress, epigenetic modification and immune modulation) glutamine metabolism drives cancer growth and progression, and present data that inhibition of glutamine utilization can lead to radiosensitization in preclinical models. Future research is needed in the clinical realm to determine whether glutamine antagonism is a feasible synergistic therapy that can be combined with radiotherapy. Frontiers Media S.A. 2022-11-17 /pmc/articles/PMC9712788/ /pubmed/36465373 http://dx.doi.org/10.3389/fonc.2022.1070514 Text en Copyright © 2022 Alden, Kamran, Bashjawish and Simone https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Alden, Ryan S.
Kamran, Mohammad Zahid
Bashjawish, Bassel A.
Simone, Brittany A.
Glutamine metabolism and radiosensitivity: Beyond the Warburg effect
title Glutamine metabolism and radiosensitivity: Beyond the Warburg effect
title_full Glutamine metabolism and radiosensitivity: Beyond the Warburg effect
title_fullStr Glutamine metabolism and radiosensitivity: Beyond the Warburg effect
title_full_unstemmed Glutamine metabolism and radiosensitivity: Beyond the Warburg effect
title_short Glutamine metabolism and radiosensitivity: Beyond the Warburg effect
title_sort glutamine metabolism and radiosensitivity: beyond the warburg effect
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712788/
https://www.ncbi.nlm.nih.gov/pubmed/36465373
http://dx.doi.org/10.3389/fonc.2022.1070514
work_keys_str_mv AT aldenryans glutaminemetabolismandradiosensitivitybeyondthewarburgeffect
AT kamranmohammadzahid glutaminemetabolismandradiosensitivitybeyondthewarburgeffect
AT bashjawishbassela glutaminemetabolismandradiosensitivitybeyondthewarburgeffect
AT simonebrittanya glutaminemetabolismandradiosensitivitybeyondthewarburgeffect