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Impact of interaction networks of B cells with other cells on tumorigenesis, progression and response to immunotherapy of renal cell carcinoma: A review

Ample evidence indicates that the development and progression of renal cell carcinoma (RCC) are complex pathological processes involving interactions between tumor cells, immune cells and stromal components. Tumor infiltrated immune cells determine whether tumor advancement is promoted or inhibited....

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Autores principales: Wang, Yu-qi, Chen, Wen-jin, Li, Wen-yan, Pan, Xiu-wu, Cui, Xin−gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712799/
https://www.ncbi.nlm.nih.gov/pubmed/36465392
http://dx.doi.org/10.3389/fonc.2022.995519
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author Wang, Yu-qi
Chen, Wen-jin
Li, Wen-yan
Pan, Xiu-wu
Cui, Xin−gang
author_facet Wang, Yu-qi
Chen, Wen-jin
Li, Wen-yan
Pan, Xiu-wu
Cui, Xin−gang
author_sort Wang, Yu-qi
collection PubMed
description Ample evidence indicates that the development and progression of renal cell carcinoma (RCC) are complex pathological processes involving interactions between tumor cells, immune cells and stromal components. Tumor infiltrated immune cells determine whether tumor advancement is promoted or inhibited. Among them, infiltrated B lymphocytes are present in all stages of RCC, playing a major role in determining tumor formation and advancement, as an essential part in the tumor microenvironment (TME). Although the advent of targeted and immune therapies has remarkably improved the survival of patients with advanced RCC, few cases can achieve complete response due to drug resistance. In this review article, we intend to summary the recent studies that outline the interaction networks of B cells with other cells, discuss the role of B cells in RCC development and progression, and assess their impact on RCC immunotherapy.
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spelling pubmed-97127992022-12-02 Impact of interaction networks of B cells with other cells on tumorigenesis, progression and response to immunotherapy of renal cell carcinoma: A review Wang, Yu-qi Chen, Wen-jin Li, Wen-yan Pan, Xiu-wu Cui, Xin−gang Front Oncol Oncology Ample evidence indicates that the development and progression of renal cell carcinoma (RCC) are complex pathological processes involving interactions between tumor cells, immune cells and stromal components. Tumor infiltrated immune cells determine whether tumor advancement is promoted or inhibited. Among them, infiltrated B lymphocytes are present in all stages of RCC, playing a major role in determining tumor formation and advancement, as an essential part in the tumor microenvironment (TME). Although the advent of targeted and immune therapies has remarkably improved the survival of patients with advanced RCC, few cases can achieve complete response due to drug resistance. In this review article, we intend to summary the recent studies that outline the interaction networks of B cells with other cells, discuss the role of B cells in RCC development and progression, and assess their impact on RCC immunotherapy. Frontiers Media S.A. 2022-11-17 /pmc/articles/PMC9712799/ /pubmed/36465392 http://dx.doi.org/10.3389/fonc.2022.995519 Text en Copyright © 2022 Wang, Chen, Li, Pan and Cui https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wang, Yu-qi
Chen, Wen-jin
Li, Wen-yan
Pan, Xiu-wu
Cui, Xin−gang
Impact of interaction networks of B cells with other cells on tumorigenesis, progression and response to immunotherapy of renal cell carcinoma: A review
title Impact of interaction networks of B cells with other cells on tumorigenesis, progression and response to immunotherapy of renal cell carcinoma: A review
title_full Impact of interaction networks of B cells with other cells on tumorigenesis, progression and response to immunotherapy of renal cell carcinoma: A review
title_fullStr Impact of interaction networks of B cells with other cells on tumorigenesis, progression and response to immunotherapy of renal cell carcinoma: A review
title_full_unstemmed Impact of interaction networks of B cells with other cells on tumorigenesis, progression and response to immunotherapy of renal cell carcinoma: A review
title_short Impact of interaction networks of B cells with other cells on tumorigenesis, progression and response to immunotherapy of renal cell carcinoma: A review
title_sort impact of interaction networks of b cells with other cells on tumorigenesis, progression and response to immunotherapy of renal cell carcinoma: a review
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712799/
https://www.ncbi.nlm.nih.gov/pubmed/36465392
http://dx.doi.org/10.3389/fonc.2022.995519
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