Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages

BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilises the angiotensin-converting enzyme 2 (ACE2) transmembrane peptidase as cellular entry receptor. However, whether SARS-CoV-2 in the alveolar compartment is strictly ACE2-dependent and to what extent virus-induced tissue...

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Detalles Bibliográficos
Autores principales: Hönzke, Katja, Obermayer, Benedikt, Mache, Christin, Fathykova, Diana, Kessler, Mirjana, Dökel, Simon, Wyler, Emanuel, Baumgardt, Morris, Löwa, Anna, Hoffmann, Karen, Graff, Patrick, Schulze, Jessica, Mieth, Maren, Hellwig, Katharina, Demir, Zeynep, Biere, Barbara, Brunotte, Linda, Mecate-Zambrano, Angeles, Bushe, Judith, Dohmen, Melanie, Hinze, Christian, Elezkurtaj, Sefer, Tönnies, Mario, Bauer, Torsten T., Eggeling, Stephan, Tran, Hong-Linh, Schneider, Paul, Neudecker, Jens, Rückert, Jens C., Schmidt-Ott, Kai M., Busch, Jonas, Klauschen, Frederick, Horst, David, Radbruch, Helena, Radke, Josefine, Heppner, Frank, Corman, Victor M., Niemeyer, Daniela, Müller, Marcel A., Goffinet, Christine, Mothes, Ronja, Pascual-Reguant, Anna, Hauser, Anja Erika, Beule, Dieter, Landthaler, Markus, Ludwig, Stephan, Suttorp, Norbert, Witzenrath, Martin, Gruber, Achim D., Drosten, Christian, Sander, Leif-Erik, Wolff, Thorsten, Hippenstiel, Stefan, Hocke, Andreas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2022
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712848/
https://www.ncbi.nlm.nih.gov/pubmed/35728978
http://dx.doi.org/10.1183/13993003.02725-2021

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