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Inspiratory hyperoxia suppresses lung cancer metastasis through a MYC/SLC1A5-dependent metabolic pathway
The lack of knowledge about the effect of inspiratory hyperoxia on the lung-specific tumour microenvironment and progression of lung cancer has attracted considerable attention. This study proposes that inspiratory hyperoxia has special significance for the malignant phenotype of lung cancer cells....
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Respiratory Society
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712851/ https://www.ncbi.nlm.nih.gov/pubmed/35680143 http://dx.doi.org/10.1183/13993003.00062-2022 |
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author | Liu, Xiucheng Qin, Hao Li, Zheng Lv, Yin Feng, Shoujie Zhuang, Wei Quan, Xiaoyu Guo, Chen Chen, Chang Zhang, Hao |
author_facet | Liu, Xiucheng Qin, Hao Li, Zheng Lv, Yin Feng, Shoujie Zhuang, Wei Quan, Xiaoyu Guo, Chen Chen, Chang Zhang, Hao |
author_sort | Liu, Xiucheng |
collection | PubMed |
description | The lack of knowledge about the effect of inspiratory hyperoxia on the lung-specific tumour microenvironment and progression of lung cancer has attracted considerable attention. This study proposes that inspiratory hyperoxia has special significance for the malignant phenotype of lung cancer cells. The effects of different oxygenation parameters on the proliferation, apoptosis, invasion and migration of lung cancer cells were systematically evaluated in vitro and in vivo. Our results reveal that inspiratory hyperoxia treatment (60% oxygen, 6 h·day(−1)) not only has no tumour progression-promoting effects, but also suppresses lung cancer metastasis and promotes long-term survival. In addition, we combined transcriptome, proteome and metabolome analysis and found that hyperoxia treatment induced significant intracellular metabolic changes in lung cancer cells. Overall, we established that MYC/SLC1A5-induced metabolic reprogramming and glutamine addiction is a new mechanism that drives lung cancer metastasis, which can be significantly suppressed by inspiratory hyperoxia treatment. These findings are relevant to the debate on the perils, promises and antitumour effect of inspiratory hyperoxia, especially for patients with lung cancer. |
format | Online Article Text |
id | pubmed-9712851 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | European Respiratory Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-97128512022-12-02 Inspiratory hyperoxia suppresses lung cancer metastasis through a MYC/SLC1A5-dependent metabolic pathway Liu, Xiucheng Qin, Hao Li, Zheng Lv, Yin Feng, Shoujie Zhuang, Wei Quan, Xiaoyu Guo, Chen Chen, Chang Zhang, Hao Eur Respir J Original Research Articles The lack of knowledge about the effect of inspiratory hyperoxia on the lung-specific tumour microenvironment and progression of lung cancer has attracted considerable attention. This study proposes that inspiratory hyperoxia has special significance for the malignant phenotype of lung cancer cells. The effects of different oxygenation parameters on the proliferation, apoptosis, invasion and migration of lung cancer cells were systematically evaluated in vitro and in vivo. Our results reveal that inspiratory hyperoxia treatment (60% oxygen, 6 h·day(−1)) not only has no tumour progression-promoting effects, but also suppresses lung cancer metastasis and promotes long-term survival. In addition, we combined transcriptome, proteome and metabolome analysis and found that hyperoxia treatment induced significant intracellular metabolic changes in lung cancer cells. Overall, we established that MYC/SLC1A5-induced metabolic reprogramming and glutamine addiction is a new mechanism that drives lung cancer metastasis, which can be significantly suppressed by inspiratory hyperoxia treatment. These findings are relevant to the debate on the perils, promises and antitumour effect of inspiratory hyperoxia, especially for patients with lung cancer. European Respiratory Society 2022-12-01 /pmc/articles/PMC9712851/ /pubmed/35680143 http://dx.doi.org/10.1183/13993003.00062-2022 Text en Copyright ©The authors 2022. https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org) |
spellingShingle | Original Research Articles Liu, Xiucheng Qin, Hao Li, Zheng Lv, Yin Feng, Shoujie Zhuang, Wei Quan, Xiaoyu Guo, Chen Chen, Chang Zhang, Hao Inspiratory hyperoxia suppresses lung cancer metastasis through a MYC/SLC1A5-dependent metabolic pathway |
title | Inspiratory hyperoxia suppresses lung cancer metastasis through a MYC/SLC1A5-dependent metabolic pathway |
title_full | Inspiratory hyperoxia suppresses lung cancer metastasis through a MYC/SLC1A5-dependent metabolic pathway |
title_fullStr | Inspiratory hyperoxia suppresses lung cancer metastasis through a MYC/SLC1A5-dependent metabolic pathway |
title_full_unstemmed | Inspiratory hyperoxia suppresses lung cancer metastasis through a MYC/SLC1A5-dependent metabolic pathway |
title_short | Inspiratory hyperoxia suppresses lung cancer metastasis through a MYC/SLC1A5-dependent metabolic pathway |
title_sort | inspiratory hyperoxia suppresses lung cancer metastasis through a myc/slc1a5-dependent metabolic pathway |
topic | Original Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712851/ https://www.ncbi.nlm.nih.gov/pubmed/35680143 http://dx.doi.org/10.1183/13993003.00062-2022 |
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