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Dimers of D76N-β(2)-microglobulin display potent antiamyloid aggregation activity

Self-association of WT β(2-)microglobulin (WT-β(2)m) into amyloid fibrils is associated with the disorder dialysis related amyloidosis. In the familial variant D76N-β(2)m, the single amino acid substitution enhances the aggregation propensity of the protein dramatically and gives rise to a disorder...

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Detalles Bibliográficos
Autores principales:	Maya-Martinez, Roberto, Xu, Yong, Guthertz, Nicolas, Walko, Martin, Karamanos, Theodoros K., Sobott, Frank, Breeze, Alexander L., Radford, Sheena E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712992/ https://www.ncbi.nlm.nih.gov/pubmed/36328246 http://dx.doi.org/10.1016/j.jbc.2022.102659

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