Transfusion burden in early childhood plays an important role in iron overload in Diamond‐Blackfan anaemia

In Diamond‐Blackfan anaemia (DBA), iron overload (IO) is common in transfusion‐dependent patients, yet has also been reported in non‐transfusion‐dependent patients. We explored the incidence of IO in transfusion‐dependent and non‐transfusion‐dependent DBA patients. We observed hepatic IO in 65% of p...

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Autores principales: de Wilde, Jonathan R. A., van Dooijeweert, Birgit, van Vuren, Annelies J., Huisman, Elise J., Smiers, Frans J., van der Veer, Arian, van Wijk, Richard, van Solinge, Wouter W., Nieuwenhuis, Edward E. S., van Beers, Eduard J., Bartels, Marije
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713217/
https://www.ncbi.nlm.nih.gov/pubmed/36467824
http://dx.doi.org/10.1002/jha2.524
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author de Wilde, Jonathan R. A.
van Dooijeweert, Birgit
van Vuren, Annelies J.
Huisman, Elise J.
Smiers, Frans J.
van der Veer, Arian
van Wijk, Richard
van Solinge, Wouter W.
Nieuwenhuis, Edward E. S.
van Beers, Eduard J.
Bartels, Marije
author_facet de Wilde, Jonathan R. A.
van Dooijeweert, Birgit
van Vuren, Annelies J.
Huisman, Elise J.
Smiers, Frans J.
van der Veer, Arian
van Wijk, Richard
van Solinge, Wouter W.
Nieuwenhuis, Edward E. S.
van Beers, Eduard J.
Bartels, Marije
author_sort de Wilde, Jonathan R. A.
collection PubMed
description In Diamond‐Blackfan anaemia (DBA), iron overload (IO) is common in transfusion‐dependent patients, yet has also been reported in non‐transfusion‐dependent patients. We explored the incidence of IO in transfusion‐dependent and non‐transfusion‐dependent DBA patients. We observed hepatic IO in 65% of patients analysed with MRI, including three patients that were only treated with transfusions in the past. Whereas overall ferritin levels and liver iron content correlated, ferritin levels did not reflect total body iron adequately. Our data suggest that transfusion burden in the past plays an important role in IO in DBA, and should be taken into account during follow up.
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spelling pubmed-97132172022-12-02 Transfusion burden in early childhood plays an important role in iron overload in Diamond‐Blackfan anaemia de Wilde, Jonathan R. A. van Dooijeweert, Birgit van Vuren, Annelies J. Huisman, Elise J. Smiers, Frans J. van der Veer, Arian van Wijk, Richard van Solinge, Wouter W. Nieuwenhuis, Edward E. S. van Beers, Eduard J. Bartels, Marije EJHaem Short Reports In Diamond‐Blackfan anaemia (DBA), iron overload (IO) is common in transfusion‐dependent patients, yet has also been reported in non‐transfusion‐dependent patients. We explored the incidence of IO in transfusion‐dependent and non‐transfusion‐dependent DBA patients. We observed hepatic IO in 65% of patients analysed with MRI, including three patients that were only treated with transfusions in the past. Whereas overall ferritin levels and liver iron content correlated, ferritin levels did not reflect total body iron adequately. Our data suggest that transfusion burden in the past plays an important role in IO in DBA, and should be taken into account during follow up. John Wiley and Sons Inc. 2022-08-30 /pmc/articles/PMC9713217/ /pubmed/36467824 http://dx.doi.org/10.1002/jha2.524 Text en © 2022 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Reports
de Wilde, Jonathan R. A.
van Dooijeweert, Birgit
van Vuren, Annelies J.
Huisman, Elise J.
Smiers, Frans J.
van der Veer, Arian
van Wijk, Richard
van Solinge, Wouter W.
Nieuwenhuis, Edward E. S.
van Beers, Eduard J.
Bartels, Marije
Transfusion burden in early childhood plays an important role in iron overload in Diamond‐Blackfan anaemia
title Transfusion burden in early childhood plays an important role in iron overload in Diamond‐Blackfan anaemia
title_full Transfusion burden in early childhood plays an important role in iron overload in Diamond‐Blackfan anaemia
title_fullStr Transfusion burden in early childhood plays an important role in iron overload in Diamond‐Blackfan anaemia
title_full_unstemmed Transfusion burden in early childhood plays an important role in iron overload in Diamond‐Blackfan anaemia
title_short Transfusion burden in early childhood plays an important role in iron overload in Diamond‐Blackfan anaemia
title_sort transfusion burden in early childhood plays an important role in iron overload in diamond‐blackfan anaemia
topic Short Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713217/
https://www.ncbi.nlm.nih.gov/pubmed/36467824
http://dx.doi.org/10.1002/jha2.524
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