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3′Nucleotidase/nuclease is required for Leishmania infantum clinical isolate susceptibility to miltefosine

BACKGROUND: Miltefosine treatment failure in visceral leishmaniasis in Brazil has been associated with deletion of the miltefosine susceptibility locus (MSL) in Leishmania infantum. The MSL comprises four genes, 3′-nucleotidase/nucleases (NUC1 and NUC2); helicase-like protein (HLP); and 3,2-trans-en...

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Detalles Bibliográficos
Autores principales:	Carnielli, Juliana B.T., Dave, Anuja, Romano, Audrey, Forrester, Sarah, de Faria, Pedro R., Monti-Rocha, Renata, Costa, Carlos H.N., Dietze, Reynaldo, Graham, Ian A., Mottram, Jeremy C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713291/ https://www.ncbi.nlm.nih.gov/pubmed/36462405 http://dx.doi.org/10.1016/j.ebiom.2022.104378

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