Cargando…

Study of the anticancer effect of new quinazolinone hydrazine derivatives as receptor tyrosine kinase inhibitors

The advent of novel receptor tyrosine kinase inhibitors has provided an important therapeutic tool for cancer patients. In this study, a series of quinazolinone hydrazide triazole derivatives were designed and synthesized as novel MET (c-MET) receptor tyrosine kinase inhibitors. The antiproliferativ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mortazavi, Motahareh, Divar, Masoumeh, Damghani, Tahereh, Moosavi, Fatemeh, Saso, Luciano, Pirhadi, Somayeh, Khoshneviszadeh, Mehdi, Edraki, Najmeh, Firuzi, Omidreza
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713320/ https://www.ncbi.nlm.nih.gov/pubmed/36465863 http://dx.doi.org/10.3389/fchem.2022.969559

Ejemplares similares

Novel quinazoline-1,2,3-triazole hybrids with anticancer and MET kinase targeting properties
por: Mortazavi, Motahareh, et al.
Publicado: (2023)

Imidazopyridine hydrazone derivatives exert antiproliferative effect on lung and pancreatic cancer cells and potentially inhibit receptor tyrosine kinases including c-Met
por: Damghani, Tahereh, et al.
Publicado: (2021)

Novel 5-oxo-hexahydroquinoline derivatives: design, synthesis, in vitro P-glycoprotein-mediated multidrug resistance reversal profile and molecular dynamics simulation study
por: Shahraki, Omolbanin, et al.
Publicado: (2017)

5-Oxo-hexahydroquinoline Derivatives and Their Tetrahydroquinoline Counterparts as Multidrug Resistance Reversal Agents
por: Shahraki, Omolbanin, et al.
Publicado: (2020)

Design and Synthesis of Novel 1-hydroxy-2,4,5-triaryl Imidazole Derivatives as Anti-cytokine Agents
por: Haghighijoo, Zahra, et al.
Publicado: (2020)

Modulation of neurotrophic signaling pathways by polyphenols
por: Moosavi, Fatemeh, et al.
Publicado: (2015)

Phenanthrotriazine Derivatives Containing Arylidine Hydrazone Moieties as Novel Potential c-Met Inhibitors with Anticancer Effect
por: Edraki, Najmeh, et al.
Publicado: (2021)

Novel Cytotoxic Phenanthro-triazine-3-thiol Derivatives as Potential DNA Intercalators and Bcl-2 Inhibitors
por: Khoshneviszadeh, Mehdi, et al.
Publicado: (2021)

Oxidative Aromatization, Cytotoxic Activity Evaluation and Conformational Study of Novel 7-aryl-10, 11-dihydro-7H-chromeno [4, 3-b]quinoline-6, 8(9H, 12H)-dione Derivatives.
por: Motamedi, Radineh, et al.
Publicado: (2014)

Modulation of ERK1/2 and Akt Pathways Involved in the Neurotrophic Action of Caffeic Acid Alkyl Esters
por: Hosseini, Razieh, et al.
Publicado: (2018)

Cinnamomum verum J. Presl. Bark essential oil: in vitro investigation of anti-cholinesterase, anti-BACE1, and neuroprotective activity
por: Saeedi, Mina, et al.
Publicado: (2022)

Correction: Cinnamomum verum J. Presl. Bark essential oil: in vitro investigation of anti-cholinesterase, anti-BACE1, and neuroprotective activity
por: Saeedi, Mina, et al.
Publicado: (2022)

Alignment independent 3D-QSAR, quantum calculations and molecular docking of Mer specific tyrosine kinase inhibitors as anticancer drugs
por: Shiri, Fereshteh, et al.
Publicado: (2016)

Design, synthesis, cytotoxicity evaluation and docking studies of 1,2,4-triazine derivatives bearing different arylidene-hydrazinyl moieties as potential mTOR inhibitors
por: Ranjbar, Sara, et al.
Publicado: (2018)

Synthesis, biological evaluation and molecular docking analysis of vaniline–benzylidenehydrazine hybrids as potent tyrosinase inhibitors
por: Iraji, Aida, et al.
Publicado: (2020)

Novel 9-(alkylthio)-Acenaphtho[1,2-e]-1,2,4-triazine derivatives: synthesis, cytotoxic activity and molecular docking studies on B-cell lymphoma 2 (Bcl-2)
por: Mohammadi, Mohammad K, et al.
Publicado: (2014)

Benzylidene-6-hydroxy-3,4-dihydronaphthalenone chalconoids as potent tyrosinase inhibitors
por: Ranjbar, Sara, et al.
Publicado: (2021)

Synthesis and anticancer activity of novel quinazolinone-based rhodanines
por: El-Sayed, Sherihan, et al.
Publicado: (2017)

Oxidative Stress in Amyotrophic Lateral Sclerosis: Pathophysiology and Opportunities for Pharmacological Intervention
por: Cunha-Oliveira, Teresa, et al.
Publicado: (2020)

Synthesis and cytotoxic evaluation of novel quinazolinone derivatives as potential anticancer agents
por: Poorirani, Safoora, et al.
Publicado: (2018)

Viral 3CL(pro) as a Target for Antiviral Intervention Using Milk-Derived Bioactive Peptides
por: Behzadipour, Yasaman, et al.
Publicado: (2021)

In Silico Screening of IL-1β Production Inhibitors Using Chemometric Tools
por: Sakhteman, Amirhossein, et al.
Publicado: (2017)

Targeting EGFR Tyrosine Kinase: Design, Synthesis and Biological Evaluation of Novel Quinazolinone Derivatives
por: Nematpour, Manijeh, et al.
Publicado: (2022)

Assessment of the Cytotoxic Effect of a Series of 1,4-Dihydropyridine Derivatives Against Human Cancer Cells
por: Razzaghi-Asl, Nima, et al.
Publicado: (2016)

Synthesis, In Silico and In Vitro Assessment of New Quinazolinones as Anticancer Agents via Potential AKT Inhibition
por: Noser, Ahmed A., et al.
Publicado: (2020)

Diterpenoids from Roots of Salvia lachnocalyx; In-silico and In-vitro Toxicity against Human Cancer Cell Lines
por: Hadavand Mirzaei, Hossein, et al.
Publicado: (2020)

Phytochemical Analysis and Biological Activity of Salvia compressa Vent.
por: Noorbakhsh, Firoozeh, et al.
Publicado: (2022)

Cytotoxic furanosesquiterpenoids and steroids from Ircinia mutans sponges
por: Heidary Jamebozorgi, Fatemeh, et al.
Publicado: (2021)

Iridium-catalysed direct sulfamidation of quinazolinones
por: Feng, Yadong, et al.
Publicado: (2018)

Quinazolinones, the Winning Horse in Drug Discovery
por: Alsibaee, Aishah M., et al.
Publicado: (2023)

Synthesis and Cytotoxicity Study of New Cyclopenta [b] quinoline-1,8-dione Derivatives
por: Miri, Ramin, et al.
Publicado: (2011)

Uses of 2-Ethoxy-4(3H) quinazolinone in Synthesis of Quinazoline and Quinazolinone Derivatives of Antimicrobial Activity: The Solvent Effect
por: El-Hashash, Maher A., et al.
Publicado: (2012)

Cytotoxic, Antioxidant and Antimicrobial Activities and Phenolic Contents of Eleven Salvia Species from Iran
por: Firuzi, Omidreza, et al.
Publicado: (2013)

Microwave-Assisted Synthesis of Quinazolines and Quinazolinones: An Overview
por: Mohammadkhani, Leyla, et al.
Publicado: (2020)

Preparation of quinazolinones using biosynthesized silver nanoparticles
por: Safaei-Ghomi, Javad, et al.
Publicado: (2022)

Recent advances and prospects in the organocatalytic synthesis of quinazolinones
por: Borah, Biplob, et al.
Publicado: (2022)

Recent advances in the pharmacological diversification of quinazoline/quinazolinone hybrids
por: Auti, Prashant S., et al.
Publicado: (2020)

Enantioselective Copper‐Catalyzed Borylative Cyclization for the Synthesis of Quinazolinones
por: Dherbassy, Quentin, et al.
Publicado: (2021)

A Bifurcated Multicomponent Synthesis Approach to Polycyclic Quinazolinones
por: Xu, Ruixue, et al.
Publicado: (2022)

Production of a recyclable nanobiocatalyst to synthesize quinazolinone derivatives
por: Budhiraja, Meenakshi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_gs2ku5rl8t58685qmbl5tf58cs