Discovery of (R)-2-amino-3-triazolpropanoic acid derivatives as NMDA receptor glycine site agonists with GluN2 subunit-specific activity

N-Methyl-d-aspartate (NMDA) receptors play critical roles in central nervous system function and are involved in variety of brain disorders. We previously developed a series of (R)-3-(5-furanyl)carboxamido-2-aminopropanoic acid glycine site agonists with pronounced variation in activity among NMDA r...

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Detalles Bibliográficos
Autores principales: Zhao, Fabao, Mazis, Georgios, Yi, Feng, Lotti, James S., Layeux, Michael S., Schultz, Eric P., Bunch, Lennart, Hansen, Kasper B., Clausen, Rasmus P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713482/
https://www.ncbi.nlm.nih.gov/pubmed/36465862
http://dx.doi.org/10.3389/fchem.2022.1008233

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