Decitabine increases neoantigen and cancer testis antigen expression to enhance T-cell–mediated toxicity against glioblastoma

BACKGROUND: Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults. Despite maximal treatment, median survival remains dismal at 14–24 months. Immunotherapies, such as checkpoint inhibition, have revolutionized management of some cancers but have little benefit for GBM pat...

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Detalles Bibliográficos
Autores principales: Ma, Ruichong, Rei, Margarida, Woodhouse, Isaac, Ferris, Katherine, Kirschner, Sophie, Chandran, Anandhakumar, Gileadi, Uzi, Chen, Ji-Li, Pereira Pinho, Mariana, Ariosa-Morejon, Yoanna, Kriaucionis, Skirmantas, Ternette, Nicola, Koohy, Hashem, Ansorge, Olaf, Ogg, Graham, Plaha, Puneet, Cerundolo, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713507/
https://www.ncbi.nlm.nih.gov/pubmed/35468205
http://dx.doi.org/10.1093/neuonc/noac107

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