Heterozygous Mutations in Aromatic Amino Acid Synthesis Genes Trigger TOR Pathway Activation in Saccharomyces cerevisiae.

The highly conserved complexes of Target of Rapamycin (TORC1 and TORC2) are central regulators to many vital cellular processes including growth and autophagy in response to nutrient availability. Previous research has extensively elucidated exogenous nutrient control on TORC1/TORC2; however, little...

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Autores principales: Schoonover, Makailyn G, Chilson, Eon C, Strome, Erin D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2022
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713580/
https://www.ncbi.nlm.nih.gov/pubmed/36468155
http://dx.doi.org/10.17912/micropub.biology.000685
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author Schoonover, Makailyn G
Chilson, Eon C
Strome, Erin D
author_facet Schoonover, Makailyn G
Chilson, Eon C
Strome, Erin D
author_sort Schoonover, Makailyn G
collection PubMed
description The highly conserved complexes of Target of Rapamycin (TORC1 and TORC2) are central regulators to many vital cellular processes including growth and autophagy in response to nutrient availability. Previous research has extensively elucidated exogenous nutrient control on TORC1/TORC2; however, little is known about the potential alteration of nutrient pools from mutations in biosynthesis pathways and their impact on Tor pathway activity. Here, we analyze the impacts of heterozygous mutations in aromatic amino acid biosynthesis genes on TOR signaling via differential expression of genes downstream of TORC1 and autophagy induction for TORC1 and TORC2 activity.
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spelling pubmed-97135802022-12-02 Heterozygous Mutations in Aromatic Amino Acid Synthesis Genes Trigger TOR Pathway Activation in Saccharomyces cerevisiae. Schoonover, Makailyn G Chilson, Eon C Strome, Erin D MicroPubl Biol New Finding The highly conserved complexes of Target of Rapamycin (TORC1 and TORC2) are central regulators to many vital cellular processes including growth and autophagy in response to nutrient availability. Previous research has extensively elucidated exogenous nutrient control on TORC1/TORC2; however, little is known about the potential alteration of nutrient pools from mutations in biosynthesis pathways and their impact on Tor pathway activity. Here, we analyze the impacts of heterozygous mutations in aromatic amino acid biosynthesis genes on TOR signaling via differential expression of genes downstream of TORC1 and autophagy induction for TORC1 and TORC2 activity. Caltech Library 2022-11-16 /pmc/articles/PMC9713580/ /pubmed/36468155 http://dx.doi.org/10.17912/micropub.biology.000685 Text en Copyright: © 2022 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle New Finding
Schoonover, Makailyn G
Chilson, Eon C
Strome, Erin D
Heterozygous Mutations in Aromatic Amino Acid Synthesis Genes Trigger TOR Pathway Activation in Saccharomyces cerevisiae.
title Heterozygous Mutations in Aromatic Amino Acid Synthesis Genes Trigger TOR Pathway Activation in Saccharomyces cerevisiae.
title_full Heterozygous Mutations in Aromatic Amino Acid Synthesis Genes Trigger TOR Pathway Activation in Saccharomyces cerevisiae.
title_fullStr Heterozygous Mutations in Aromatic Amino Acid Synthesis Genes Trigger TOR Pathway Activation in Saccharomyces cerevisiae.
title_full_unstemmed Heterozygous Mutations in Aromatic Amino Acid Synthesis Genes Trigger TOR Pathway Activation in Saccharomyces cerevisiae.
title_short Heterozygous Mutations in Aromatic Amino Acid Synthesis Genes Trigger TOR Pathway Activation in Saccharomyces cerevisiae.
title_sort heterozygous mutations in aromatic amino acid synthesis genes trigger tor pathway activation in saccharomyces cerevisiae.
topic New Finding
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713580/
https://www.ncbi.nlm.nih.gov/pubmed/36468155
http://dx.doi.org/10.17912/micropub.biology.000685
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AT stromeerind heterozygousmutationsinaromaticaminoacidsynthesisgenestriggertorpathwayactivationinsaccharomycescerevisiae

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