Knockdown of Ift88 in fibroblasts causes extracellular matrix remodeling and decreases conduction velocity in cardiomyocyte monolayers

Background: Atrial fibrosis plays an important role in the development and persistence of atrial fibrillation by promoting reentry. Primary cilia have been identified as a regulator of fibroblasts (FB) activation and extracellular matrix (ECM) deposition. We hypothesized that selective reduction of...

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Detalles Bibliográficos
Autores principales: Ernault, Auriane C., Kawasaki, Makiri, Fabrizi, Benedetta, Montañés-Agudo, Pablo, Amersfoorth, Shirley C. M., Al-Shama, Rushd F. M., Coronel, Ruben, De Groot, Joris R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713696/
https://www.ncbi.nlm.nih.gov/pubmed/36467697
http://dx.doi.org/10.3389/fphys.2022.1057200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713696/
https://www.ncbi.nlm.nih.gov/pubmed/36467697
http://dx.doi.org/10.3389/fphys.2022.1057200

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