Simultaneous detection of novel genes and SNPs by adaptive p-value combination

Combining SNP p-values from GWAS summary data is a promising strategy for detecting novel genetic factors. Existing statistical methods for the p-value-based SNP-set testing confront two challenges. First, the statistical power of different methods depends on unknown patterns of genetic effects that...

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Detalles Bibliográficos
Autores principales: Chen, Xiaohui, Zhang, Hong, Liu, Ming, Deng, Hong-Wen, Wu, Zheyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713700/
https://www.ncbi.nlm.nih.gov/pubmed/36468009
http://dx.doi.org/10.3389/fgene.2022.1009428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713700/
https://www.ncbi.nlm.nih.gov/pubmed/36468009
http://dx.doi.org/10.3389/fgene.2022.1009428

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