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Resonant Enhancement of Polymer–Cell Optostimulation by a Plasmonic Metasurface

[Image: see text] Organic semiconductors have shown great potential as efficient bioelectronic materials. Specifically, photovoltaic polymers such as the workhorse poly(thiophene) derivatives, when stimulated with visible light, can depolarize neurons and generate action potentials, an effect that h...

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Autores principales: Maity, Arijit, Perotto, Sara, Moschetta, Matteo, Hua, Huang, Sardar, Samim, Paternò, Giuseppe Maria, Tian, Jingyi, Klein, Maciej, Adamo, Giorgio, Lanzani, Guglielmo, Soci, Cesare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713778/
https://www.ncbi.nlm.nih.gov/pubmed/36467911
http://dx.doi.org/10.1021/acsomega.2c04812
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author Maity, Arijit
Perotto, Sara
Moschetta, Matteo
Hua, Huang
Sardar, Samim
Paternò, Giuseppe Maria
Tian, Jingyi
Klein, Maciej
Adamo, Giorgio
Lanzani, Guglielmo
Soci, Cesare
author_facet Maity, Arijit
Perotto, Sara
Moschetta, Matteo
Hua, Huang
Sardar, Samim
Paternò, Giuseppe Maria
Tian, Jingyi
Klein, Maciej
Adamo, Giorgio
Lanzani, Guglielmo
Soci, Cesare
author_sort Maity, Arijit
collection PubMed
description [Image: see text] Organic semiconductors have shown great potential as efficient bioelectronic materials. Specifically, photovoltaic polymers such as the workhorse poly(thiophene) derivatives, when stimulated with visible light, can depolarize neurons and generate action potentials, an effect that has been also employed for rescuing vision in blind rats. In this context, however, the coupling of such materials with optically resonant structures to enhance those photodriven biological effects is still in its infancy. Here, we employ the optical coupling between a nanostructured metasurface and poly(3-hexylthiophene) (P3HT) to improve the bioelectronic effects occurring upon photostimulation at the abiotic–biotic interface. In particular, we designed a spectrally tuned aluminum metasurface that can resonate with P3HT, hence augmenting the effective field experienced by the polymer. In turn, this leads to an 8-fold increase in invoked inward current in cells. This enhanced activation strategy could be useful to increase the effectiveness of P3HT-based prosthetic implants for degenerative retinal disorders.
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spelling pubmed-97137782022-12-02 Resonant Enhancement of Polymer–Cell Optostimulation by a Plasmonic Metasurface Maity, Arijit Perotto, Sara Moschetta, Matteo Hua, Huang Sardar, Samim Paternò, Giuseppe Maria Tian, Jingyi Klein, Maciej Adamo, Giorgio Lanzani, Guglielmo Soci, Cesare ACS Omega [Image: see text] Organic semiconductors have shown great potential as efficient bioelectronic materials. Specifically, photovoltaic polymers such as the workhorse poly(thiophene) derivatives, when stimulated with visible light, can depolarize neurons and generate action potentials, an effect that has been also employed for rescuing vision in blind rats. In this context, however, the coupling of such materials with optically resonant structures to enhance those photodriven biological effects is still in its infancy. Here, we employ the optical coupling between a nanostructured metasurface and poly(3-hexylthiophene) (P3HT) to improve the bioelectronic effects occurring upon photostimulation at the abiotic–biotic interface. In particular, we designed a spectrally tuned aluminum metasurface that can resonate with P3HT, hence augmenting the effective field experienced by the polymer. In turn, this leads to an 8-fold increase in invoked inward current in cells. This enhanced activation strategy could be useful to increase the effectiveness of P3HT-based prosthetic implants for degenerative retinal disorders. American Chemical Society 2022-11-16 /pmc/articles/PMC9713778/ /pubmed/36467911 http://dx.doi.org/10.1021/acsomega.2c04812 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Maity, Arijit
Perotto, Sara
Moschetta, Matteo
Hua, Huang
Sardar, Samim
Paternò, Giuseppe Maria
Tian, Jingyi
Klein, Maciej
Adamo, Giorgio
Lanzani, Guglielmo
Soci, Cesare
Resonant Enhancement of Polymer–Cell Optostimulation by a Plasmonic Metasurface
title Resonant Enhancement of Polymer–Cell Optostimulation by a Plasmonic Metasurface
title_full Resonant Enhancement of Polymer–Cell Optostimulation by a Plasmonic Metasurface
title_fullStr Resonant Enhancement of Polymer–Cell Optostimulation by a Plasmonic Metasurface
title_full_unstemmed Resonant Enhancement of Polymer–Cell Optostimulation by a Plasmonic Metasurface
title_short Resonant Enhancement of Polymer–Cell Optostimulation by a Plasmonic Metasurface
title_sort resonant enhancement of polymer–cell optostimulation by a plasmonic metasurface
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713778/
https://www.ncbi.nlm.nih.gov/pubmed/36467911
http://dx.doi.org/10.1021/acsomega.2c04812
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