Cargando…
Resonant Enhancement of Polymer–Cell Optostimulation by a Plasmonic Metasurface
[Image: see text] Organic semiconductors have shown great potential as efficient bioelectronic materials. Specifically, photovoltaic polymers such as the workhorse poly(thiophene) derivatives, when stimulated with visible light, can depolarize neurons and generate action potentials, an effect that h...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713778/ https://www.ncbi.nlm.nih.gov/pubmed/36467911 http://dx.doi.org/10.1021/acsomega.2c04812 |
_version_ | 1784842084347281408 |
---|---|
author | Maity, Arijit Perotto, Sara Moschetta, Matteo Hua, Huang Sardar, Samim Paternò, Giuseppe Maria Tian, Jingyi Klein, Maciej Adamo, Giorgio Lanzani, Guglielmo Soci, Cesare |
author_facet | Maity, Arijit Perotto, Sara Moschetta, Matteo Hua, Huang Sardar, Samim Paternò, Giuseppe Maria Tian, Jingyi Klein, Maciej Adamo, Giorgio Lanzani, Guglielmo Soci, Cesare |
author_sort | Maity, Arijit |
collection | PubMed |
description | [Image: see text] Organic semiconductors have shown great potential as efficient bioelectronic materials. Specifically, photovoltaic polymers such as the workhorse poly(thiophene) derivatives, when stimulated with visible light, can depolarize neurons and generate action potentials, an effect that has been also employed for rescuing vision in blind rats. In this context, however, the coupling of such materials with optically resonant structures to enhance those photodriven biological effects is still in its infancy. Here, we employ the optical coupling between a nanostructured metasurface and poly(3-hexylthiophene) (P3HT) to improve the bioelectronic effects occurring upon photostimulation at the abiotic–biotic interface. In particular, we designed a spectrally tuned aluminum metasurface that can resonate with P3HT, hence augmenting the effective field experienced by the polymer. In turn, this leads to an 8-fold increase in invoked inward current in cells. This enhanced activation strategy could be useful to increase the effectiveness of P3HT-based prosthetic implants for degenerative retinal disorders. |
format | Online Article Text |
id | pubmed-9713778 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-97137782022-12-02 Resonant Enhancement of Polymer–Cell Optostimulation by a Plasmonic Metasurface Maity, Arijit Perotto, Sara Moschetta, Matteo Hua, Huang Sardar, Samim Paternò, Giuseppe Maria Tian, Jingyi Klein, Maciej Adamo, Giorgio Lanzani, Guglielmo Soci, Cesare ACS Omega [Image: see text] Organic semiconductors have shown great potential as efficient bioelectronic materials. Specifically, photovoltaic polymers such as the workhorse poly(thiophene) derivatives, when stimulated with visible light, can depolarize neurons and generate action potentials, an effect that has been also employed for rescuing vision in blind rats. In this context, however, the coupling of such materials with optically resonant structures to enhance those photodriven biological effects is still in its infancy. Here, we employ the optical coupling between a nanostructured metasurface and poly(3-hexylthiophene) (P3HT) to improve the bioelectronic effects occurring upon photostimulation at the abiotic–biotic interface. In particular, we designed a spectrally tuned aluminum metasurface that can resonate with P3HT, hence augmenting the effective field experienced by the polymer. In turn, this leads to an 8-fold increase in invoked inward current in cells. This enhanced activation strategy could be useful to increase the effectiveness of P3HT-based prosthetic implants for degenerative retinal disorders. American Chemical Society 2022-11-16 /pmc/articles/PMC9713778/ /pubmed/36467911 http://dx.doi.org/10.1021/acsomega.2c04812 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Maity, Arijit Perotto, Sara Moschetta, Matteo Hua, Huang Sardar, Samim Paternò, Giuseppe Maria Tian, Jingyi Klein, Maciej Adamo, Giorgio Lanzani, Guglielmo Soci, Cesare Resonant Enhancement of Polymer–Cell Optostimulation by a Plasmonic Metasurface |
title | Resonant Enhancement of Polymer–Cell Optostimulation
by a Plasmonic Metasurface |
title_full | Resonant Enhancement of Polymer–Cell Optostimulation
by a Plasmonic Metasurface |
title_fullStr | Resonant Enhancement of Polymer–Cell Optostimulation
by a Plasmonic Metasurface |
title_full_unstemmed | Resonant Enhancement of Polymer–Cell Optostimulation
by a Plasmonic Metasurface |
title_short | Resonant Enhancement of Polymer–Cell Optostimulation
by a Plasmonic Metasurface |
title_sort | resonant enhancement of polymer–cell optostimulation
by a plasmonic metasurface |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713778/ https://www.ncbi.nlm.nih.gov/pubmed/36467911 http://dx.doi.org/10.1021/acsomega.2c04812 |
work_keys_str_mv | AT maityarijit resonantenhancementofpolymercelloptostimulationbyaplasmonicmetasurface AT perottosara resonantenhancementofpolymercelloptostimulationbyaplasmonicmetasurface AT moschettamatteo resonantenhancementofpolymercelloptostimulationbyaplasmonicmetasurface AT huahuang resonantenhancementofpolymercelloptostimulationbyaplasmonicmetasurface AT sardarsamim resonantenhancementofpolymercelloptostimulationbyaplasmonicmetasurface AT paternogiuseppemaria resonantenhancementofpolymercelloptostimulationbyaplasmonicmetasurface AT tianjingyi resonantenhancementofpolymercelloptostimulationbyaplasmonicmetasurface AT kleinmaciej resonantenhancementofpolymercelloptostimulationbyaplasmonicmetasurface AT adamogiorgio resonantenhancementofpolymercelloptostimulationbyaplasmonicmetasurface AT lanzaniguglielmo resonantenhancementofpolymercelloptostimulationbyaplasmonicmetasurface AT socicesare resonantenhancementofpolymercelloptostimulationbyaplasmonicmetasurface |