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Increased expression of HMMR in renal cell carcinoma is an independent prognostic factor

The present study investigated how abnormal expression of hyaluronan-mediated mobility receptor (HMMR) in renal cell carcinoma (RCC) tissue affects the growth of RCC cells and the association between expression of HMMR and pathological staging and prognosis of patients with RCC. Reverse transcriptio...

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Detalles Bibliográficos
Autores principales: Zhang, Henglan, Li, Ling, Wang, Dongqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713828/
https://www.ncbi.nlm.nih.gov/pubmed/36478897
http://dx.doi.org/10.3892/ol.2022.13614
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author Zhang, Henglan
Li, Ling
Wang, Dongqing
author_facet Zhang, Henglan
Li, Ling
Wang, Dongqing
author_sort Zhang, Henglan
collection PubMed
description The present study investigated how abnormal expression of hyaluronan-mediated mobility receptor (HMMR) in renal cell carcinoma (RCC) tissue affects the growth of RCC cells and the association between expression of HMMR and pathological staging and prognosis of patients with RCC. Reverse transcription-quantitative PCR was used to measure the expression of HMMR mRNA in RCC tissue and cell lines. For the prediction of HMMR gene expression, The Cancer Genome Atlas online database was utilized to compare differential gene expression of HMMR in normal renal and RCC tissue. Cell Counting Kit-8 assay was used to examine cell proliferation. The expression of HMMR increased in RCC tissue and renal cancer cell lines. The expression of HMMR was an independent prognostic factor for 5-year and disease-free survival in patients with RCC. The silencing of HMMR expression decreased the expression of Cyclin B1 and inhibited the proliferation of RCC cells. Overexpression of HMMR promoted the expression of Cyclin B1 and cell proliferation. The present study demonstrated that the expression of HMMR was significantly upregulated in RCC and was an independent prognostic factor for RCC. HMMR may be involved in the occurrence of RCC by regulating Cyclin B1.
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spelling pubmed-97138282022-12-06 Increased expression of HMMR in renal cell carcinoma is an independent prognostic factor Zhang, Henglan Li, Ling Wang, Dongqing Oncol Lett Articles The present study investigated how abnormal expression of hyaluronan-mediated mobility receptor (HMMR) in renal cell carcinoma (RCC) tissue affects the growth of RCC cells and the association between expression of HMMR and pathological staging and prognosis of patients with RCC. Reverse transcription-quantitative PCR was used to measure the expression of HMMR mRNA in RCC tissue and cell lines. For the prediction of HMMR gene expression, The Cancer Genome Atlas online database was utilized to compare differential gene expression of HMMR in normal renal and RCC tissue. Cell Counting Kit-8 assay was used to examine cell proliferation. The expression of HMMR increased in RCC tissue and renal cancer cell lines. The expression of HMMR was an independent prognostic factor for 5-year and disease-free survival in patients with RCC. The silencing of HMMR expression decreased the expression of Cyclin B1 and inhibited the proliferation of RCC cells. Overexpression of HMMR promoted the expression of Cyclin B1 and cell proliferation. The present study demonstrated that the expression of HMMR was significantly upregulated in RCC and was an independent prognostic factor for RCC. HMMR may be involved in the occurrence of RCC by regulating Cyclin B1. D.A. Spandidos 2022-11-24 /pmc/articles/PMC9713828/ /pubmed/36478897 http://dx.doi.org/10.3892/ol.2022.13614 Text en Copyright: © Zhang et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Zhang, Henglan
Li, Ling
Wang, Dongqing
Increased expression of HMMR in renal cell carcinoma is an independent prognostic factor
title Increased expression of HMMR in renal cell carcinoma is an independent prognostic factor
title_full Increased expression of HMMR in renal cell carcinoma is an independent prognostic factor
title_fullStr Increased expression of HMMR in renal cell carcinoma is an independent prognostic factor
title_full_unstemmed Increased expression of HMMR in renal cell carcinoma is an independent prognostic factor
title_short Increased expression of HMMR in renal cell carcinoma is an independent prognostic factor
title_sort increased expression of hmmr in renal cell carcinoma is an independent prognostic factor
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9713828/
https://www.ncbi.nlm.nih.gov/pubmed/36478897
http://dx.doi.org/10.3892/ol.2022.13614
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