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Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells

BACKGROUND: Intervertebral disc degeneration results from a variety of etiologies, including inflammation and aging. Degenerated intervertebral discs feature down-regulated extracellular matrix synthesis, resulting in losing their ability to retain water and absorb compression. Celecoxib is a well-k...

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Detalles Bibliográficos
Autores principales:	Chen, Weisin, Yasen, Miersalijiang, Wang, Hanquan, Zhuang, Chenyang, Wang, Zixiang, Lu, Shunyi, Jiang, Libo, Lin, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714067/ https://www.ncbi.nlm.nih.gov/pubmed/36457130 http://dx.doi.org/10.1186/s40360-022-00633-y

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