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Exosomal circular RNA: a signature for lung cancer progression

Membrane vesicles having a diameter of 30–150 nm are known as exosomes. Several cancer types secrete exosomes, which may contain proteins, circular RNAs (circRNAs), microRNAs, or DNA. CircRNAs are endogenous RNAs that do not code for proteins and can create continuous and covalently closed loops. In...

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Autores principales: Hussen, Bashdar Mahmud, Abdullah, Snur Rasool, Hama Faraj, Goran Sedeeq, Rasul, Mohammed Fatih, Salihi, Abbas, Ghafouri-Fard, Soudeh, Taheri, Mohammad, Mokhtari, Majid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714134/
https://www.ncbi.nlm.nih.gov/pubmed/36457039
http://dx.doi.org/10.1186/s12935-022-02793-7
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author Hussen, Bashdar Mahmud
Abdullah, Snur Rasool
Hama Faraj, Goran Sedeeq
Rasul, Mohammed Fatih
Salihi, Abbas
Ghafouri-Fard, Soudeh
Taheri, Mohammad
Mokhtari, Majid
author_facet Hussen, Bashdar Mahmud
Abdullah, Snur Rasool
Hama Faraj, Goran Sedeeq
Rasul, Mohammed Fatih
Salihi, Abbas
Ghafouri-Fard, Soudeh
Taheri, Mohammad
Mokhtari, Majid
author_sort Hussen, Bashdar Mahmud
collection PubMed
description Membrane vesicles having a diameter of 30–150 nm are known as exosomes. Several cancer types secrete exosomes, which may contain proteins, circular RNAs (circRNAs), microRNAs, or DNA. CircRNAs are endogenous RNAs that do not code for proteins and can create continuous and covalently closed loops. In cancer pathogenesis, especially metastasis, exosomal circRNAs (exo-circRNAs) have a crucial role mainly due to the frequently aberrant expression levels within tumors. However, neither the activities nor the regulatory mechanisms of exo-circRNAs in advancing lung cancer (LC) are obvious. A better understanding of the regulation and network connections of exo-circRNAs will lead to better treatment for LCs. The main objective of the current review is to highlight the functions and mechanisms of exo-circRNAs in LC and assess the relationships between exo-circRNA dysregulation and LC progression. In addition, underline the possible therapeutic targets based on exo-circRNA modulating.
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spelling pubmed-97141342022-12-02 Exosomal circular RNA: a signature for lung cancer progression Hussen, Bashdar Mahmud Abdullah, Snur Rasool Hama Faraj, Goran Sedeeq Rasul, Mohammed Fatih Salihi, Abbas Ghafouri-Fard, Soudeh Taheri, Mohammad Mokhtari, Majid Cancer Cell Int Review Membrane vesicles having a diameter of 30–150 nm are known as exosomes. Several cancer types secrete exosomes, which may contain proteins, circular RNAs (circRNAs), microRNAs, or DNA. CircRNAs are endogenous RNAs that do not code for proteins and can create continuous and covalently closed loops. In cancer pathogenesis, especially metastasis, exosomal circRNAs (exo-circRNAs) have a crucial role mainly due to the frequently aberrant expression levels within tumors. However, neither the activities nor the regulatory mechanisms of exo-circRNAs in advancing lung cancer (LC) are obvious. A better understanding of the regulation and network connections of exo-circRNAs will lead to better treatment for LCs. The main objective of the current review is to highlight the functions and mechanisms of exo-circRNAs in LC and assess the relationships between exo-circRNA dysregulation and LC progression. In addition, underline the possible therapeutic targets based on exo-circRNA modulating. BioMed Central 2022-12-01 /pmc/articles/PMC9714134/ /pubmed/36457039 http://dx.doi.org/10.1186/s12935-022-02793-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Hussen, Bashdar Mahmud
Abdullah, Snur Rasool
Hama Faraj, Goran Sedeeq
Rasul, Mohammed Fatih
Salihi, Abbas
Ghafouri-Fard, Soudeh
Taheri, Mohammad
Mokhtari, Majid
Exosomal circular RNA: a signature for lung cancer progression
title Exosomal circular RNA: a signature for lung cancer progression
title_full Exosomal circular RNA: a signature for lung cancer progression
title_fullStr Exosomal circular RNA: a signature for lung cancer progression
title_full_unstemmed Exosomal circular RNA: a signature for lung cancer progression
title_short Exosomal circular RNA: a signature for lung cancer progression
title_sort exosomal circular rna: a signature for lung cancer progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714134/
https://www.ncbi.nlm.nih.gov/pubmed/36457039
http://dx.doi.org/10.1186/s12935-022-02793-7
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