Radiotherapy modulates tumor cell fate decisions: a review

Cancer has always been a worldwide problem, and the application of radiotherapy has greatly improved the survival rate of cancer patients. Radiotherapy can modulate multiple cell fate decisions to kill tumor cells and achieve its therapeutic effect. With the development of radiotherapy technology, h...

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Autores principales: Chen, Haoran, Han, Zhongyu, Luo, Qian, Wang, Yi, Li, Qiju, Zhou, Lisui, Zuo, Houdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714175/
https://www.ncbi.nlm.nih.gov/pubmed/36457125
http://dx.doi.org/10.1186/s13014-022-02171-7
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author Chen, Haoran
Han, Zhongyu
Luo, Qian
Wang, Yi
Li, Qiju
Zhou, Lisui
Zuo, Houdong
author_facet Chen, Haoran
Han, Zhongyu
Luo, Qian
Wang, Yi
Li, Qiju
Zhou, Lisui
Zuo, Houdong
author_sort Chen, Haoran
collection PubMed
description Cancer has always been a worldwide problem, and the application of radiotherapy has greatly improved the survival rate of cancer patients. Radiotherapy can modulate multiple cell fate decisions to kill tumor cells and achieve its therapeutic effect. With the development of radiotherapy technology, how to increase the killing effect of tumor cells and reduce the side effects on normal cells has become a new problem. In this review, we summarize the mechanisms by which radiotherapy induces tumor cell apoptosis, necrosis, necroptosis, pyroptosis, ferroptosis, autophagy, senescence, mitotic catastrophe, and cuproptosis. An in-depth understanding of these radiotherapy-related cell fate decisions can greatly improve the efficiency of radiotherapy for cancer.
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spelling pubmed-97141752022-12-02 Radiotherapy modulates tumor cell fate decisions: a review Chen, Haoran Han, Zhongyu Luo, Qian Wang, Yi Li, Qiju Zhou, Lisui Zuo, Houdong Radiat Oncol Review Cancer has always been a worldwide problem, and the application of radiotherapy has greatly improved the survival rate of cancer patients. Radiotherapy can modulate multiple cell fate decisions to kill tumor cells and achieve its therapeutic effect. With the development of radiotherapy technology, how to increase the killing effect of tumor cells and reduce the side effects on normal cells has become a new problem. In this review, we summarize the mechanisms by which radiotherapy induces tumor cell apoptosis, necrosis, necroptosis, pyroptosis, ferroptosis, autophagy, senescence, mitotic catastrophe, and cuproptosis. An in-depth understanding of these radiotherapy-related cell fate decisions can greatly improve the efficiency of radiotherapy for cancer. BioMed Central 2022-12-01 /pmc/articles/PMC9714175/ /pubmed/36457125 http://dx.doi.org/10.1186/s13014-022-02171-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Chen, Haoran
Han, Zhongyu
Luo, Qian
Wang, Yi
Li, Qiju
Zhou, Lisui
Zuo, Houdong
Radiotherapy modulates tumor cell fate decisions: a review
title Radiotherapy modulates tumor cell fate decisions: a review
title_full Radiotherapy modulates tumor cell fate decisions: a review
title_fullStr Radiotherapy modulates tumor cell fate decisions: a review
title_full_unstemmed Radiotherapy modulates tumor cell fate decisions: a review
title_short Radiotherapy modulates tumor cell fate decisions: a review
title_sort radiotherapy modulates tumor cell fate decisions: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714175/
https://www.ncbi.nlm.nih.gov/pubmed/36457125
http://dx.doi.org/10.1186/s13014-022-02171-7
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