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SPECT findings on neuropsychiatric symptoms caused by nitrous oxide abuse

OBJECTIVE: The aim of the study was to investigate the clinical, neuropsychological, and regional cerebral blood flow (rCBF) perfusion changes in patients with neuropsychiatric symptoms caused by nitrous oxide (N(2)O) abuse. METHODS: A total of 16 patients with neuropsychiatric symptoms caused by ni...

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Autores principales: Wang, Li, Yin, Lijie, Wang, Qian, Wang, Renbin, Liu, Zunjing, Dong, Mingrui, Duan, Xiaohui, Zheng, Yumin, Hong, Wen, Liu, Fang, Tie, Changle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714330/
https://www.ncbi.nlm.nih.gov/pubmed/36465302
http://dx.doi.org/10.3389/fpsyt.2022.980516
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author Wang, Li
Yin, Lijie
Wang, Qian
Wang, Renbin
Liu, Zunjing
Dong, Mingrui
Duan, Xiaohui
Zheng, Yumin
Hong, Wen
Liu, Fang
Tie, Changle
author_facet Wang, Li
Yin, Lijie
Wang, Qian
Wang, Renbin
Liu, Zunjing
Dong, Mingrui
Duan, Xiaohui
Zheng, Yumin
Hong, Wen
Liu, Fang
Tie, Changle
author_sort Wang, Li
collection PubMed
description OBJECTIVE: The aim of the study was to investigate the clinical, neuropsychological, and regional cerebral blood flow (rCBF) perfusion changes in patients with neuropsychiatric symptoms caused by nitrous oxide (N(2)O) abuse. METHODS: A total of 16 patients with neuropsychiatric symptoms caused by nitrous oxide abuse were recruited for this study. The study was carried out in the withdrawal phase of N(2)O abuse. A 925–1110 MBq (99m)Tc-ECD was administered intravenously. SPECT/CT images were collected with a low-energy and high-resolution collimator. The region uptake statistics of different brain regions of interest between patients with N(2)O abuse and normal people of the databases for younger subjects from the Scenium DB Comparison software were calculated automatically. RESULTS: The clinical manifestations of the 16 patients with neuropsychiatric symptoms were mood lability, anxiety, hallucination, delusion, agitation, confusion, and other psychiatric symptoms. In addition, 15 of the patients also complained of memory decline; 14 patients manifested numbness or paresthesia; 14 patients developed limb weakness, and their motor impairments were more severe in the lower limbs than in the upper limbs; and eight patients had urinary and defecation disturbances. In the neuropsychological examination, the BPRS score was 54.69 ± 11.48, the HAMD score was 30.00 ± 11.06, the HAMA score was 18.06 ± 5.77, the MMSE score was 28.06 ± 2.29, and the MoCA score was 25.06 ± 3.40. SPECT showed hypoperfusion in the frontal and temporal lobes, which is consistent with the clinical findings. CONCLUSION: This was the first study to demonstrate the obvious effect of N(2)O abuse on CBF in patients with neuropsychiatric symptoms. CBF perfusion imaging is helpful to detect the changes in the local brain functional activity in patients with N(2)O abuse.
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spelling pubmed-97143302022-12-02 SPECT findings on neuropsychiatric symptoms caused by nitrous oxide abuse Wang, Li Yin, Lijie Wang, Qian Wang, Renbin Liu, Zunjing Dong, Mingrui Duan, Xiaohui Zheng, Yumin Hong, Wen Liu, Fang Tie, Changle Front Psychiatry Psychiatry OBJECTIVE: The aim of the study was to investigate the clinical, neuropsychological, and regional cerebral blood flow (rCBF) perfusion changes in patients with neuropsychiatric symptoms caused by nitrous oxide (N(2)O) abuse. METHODS: A total of 16 patients with neuropsychiatric symptoms caused by nitrous oxide abuse were recruited for this study. The study was carried out in the withdrawal phase of N(2)O abuse. A 925–1110 MBq (99m)Tc-ECD was administered intravenously. SPECT/CT images were collected with a low-energy and high-resolution collimator. The region uptake statistics of different brain regions of interest between patients with N(2)O abuse and normal people of the databases for younger subjects from the Scenium DB Comparison software were calculated automatically. RESULTS: The clinical manifestations of the 16 patients with neuropsychiatric symptoms were mood lability, anxiety, hallucination, delusion, agitation, confusion, and other psychiatric symptoms. In addition, 15 of the patients also complained of memory decline; 14 patients manifested numbness or paresthesia; 14 patients developed limb weakness, and their motor impairments were more severe in the lower limbs than in the upper limbs; and eight patients had urinary and defecation disturbances. In the neuropsychological examination, the BPRS score was 54.69 ± 11.48, the HAMD score was 30.00 ± 11.06, the HAMA score was 18.06 ± 5.77, the MMSE score was 28.06 ± 2.29, and the MoCA score was 25.06 ± 3.40. SPECT showed hypoperfusion in the frontal and temporal lobes, which is consistent with the clinical findings. CONCLUSION: This was the first study to demonstrate the obvious effect of N(2)O abuse on CBF in patients with neuropsychiatric symptoms. CBF perfusion imaging is helpful to detect the changes in the local brain functional activity in patients with N(2)O abuse. Frontiers Media S.A. 2022-11-17 /pmc/articles/PMC9714330/ /pubmed/36465302 http://dx.doi.org/10.3389/fpsyt.2022.980516 Text en Copyright © 2022 Wang, Yin, Wang, Wang, Liu, Dong, Duan, Zheng, Hong, Liu and Tie. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Wang, Li
Yin, Lijie
Wang, Qian
Wang, Renbin
Liu, Zunjing
Dong, Mingrui
Duan, Xiaohui
Zheng, Yumin
Hong, Wen
Liu, Fang
Tie, Changle
SPECT findings on neuropsychiatric symptoms caused by nitrous oxide abuse
title SPECT findings on neuropsychiatric symptoms caused by nitrous oxide abuse
title_full SPECT findings on neuropsychiatric symptoms caused by nitrous oxide abuse
title_fullStr SPECT findings on neuropsychiatric symptoms caused by nitrous oxide abuse
title_full_unstemmed SPECT findings on neuropsychiatric symptoms caused by nitrous oxide abuse
title_short SPECT findings on neuropsychiatric symptoms caused by nitrous oxide abuse
title_sort spect findings on neuropsychiatric symptoms caused by nitrous oxide abuse
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714330/
https://www.ncbi.nlm.nih.gov/pubmed/36465302
http://dx.doi.org/10.3389/fpsyt.2022.980516
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