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Declined adipogenic potential of senescent MSCs due to shift in insulin signaling and altered exosome cargo
Multipotent mesenchymal stromal cells (MSCs) maintain cellular homeostasis and regulate tissue renewal and repair both by differentiating into mesodermal lineage, e.g., adipocytes, or managing the functions of differentiated cells. Insulin is a key physiological inducer of MSC differentiation into a...
Autores principales: | Voynova, Elizaveta, Kulebyakin, Konstantin, Grigorieva, Olga, Novoseletskaya, Ekaterina, Basalova, Natalia, Alexandrushkina, Natalia, Arbatskiy, Mikhail, Vigovskiy, Maxim, Sorokina, Anna, Zinoveva, Anna, Bakhchinyan, Elizaveta, Kalinina, Natalia, Akopyan, Zhanna, Tkachuk, Vsevolod, Tyurin-Kuzmin, Pyotr, Efimenko, Anastasia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714334/ https://www.ncbi.nlm.nih.gov/pubmed/36467400 http://dx.doi.org/10.3389/fcell.2022.1050489 |
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