Foxp3+ regulatory T cell therapy for tolerance in autoimmunity and solid organ transplantation

Regulatory T cells (Tregs) are critical for tolerance in humans. The exact mechanisms by which the loss of peripheral tolerance leads to the development of autoimmunity and the specific role Tregs play in allograft tolerance are not fully understood; however, this population of T cells presents a un...

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Autores principales: Sanders, Jes M., Jeyamogan, Shareni, Mathew, James M., Leventhal, Joseph R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714335/
https://www.ncbi.nlm.nih.gov/pubmed/36466912
http://dx.doi.org/10.3389/fimmu.2022.1055466
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author Sanders, Jes M.
Jeyamogan, Shareni
Mathew, James M.
Leventhal, Joseph R.
author_facet Sanders, Jes M.
Jeyamogan, Shareni
Mathew, James M.
Leventhal, Joseph R.
author_sort Sanders, Jes M.
collection PubMed
description Regulatory T cells (Tregs) are critical for tolerance in humans. The exact mechanisms by which the loss of peripheral tolerance leads to the development of autoimmunity and the specific role Tregs play in allograft tolerance are not fully understood; however, this population of T cells presents a unique opportunity in the development of targeted therapeutics. In this review, we discuss the potential roles of Foxp3+ Tregs in the development of tolerance in transplantation and autoimmunity, and the available data regarding their use as a treatment modality.
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spelling pubmed-97143352022-12-02 Foxp3+ regulatory T cell therapy for tolerance in autoimmunity and solid organ transplantation Sanders, Jes M. Jeyamogan, Shareni Mathew, James M. Leventhal, Joseph R. Front Immunol Immunology Regulatory T cells (Tregs) are critical for tolerance in humans. The exact mechanisms by which the loss of peripheral tolerance leads to the development of autoimmunity and the specific role Tregs play in allograft tolerance are not fully understood; however, this population of T cells presents a unique opportunity in the development of targeted therapeutics. In this review, we discuss the potential roles of Foxp3+ Tregs in the development of tolerance in transplantation and autoimmunity, and the available data regarding their use as a treatment modality. Frontiers Media S.A. 2022-11-17 /pmc/articles/PMC9714335/ /pubmed/36466912 http://dx.doi.org/10.3389/fimmu.2022.1055466 Text en Copyright © 2022 Sanders, Jeyamogan, Mathew and Leventhal https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Sanders, Jes M.
Jeyamogan, Shareni
Mathew, James M.
Leventhal, Joseph R.
Foxp3+ regulatory T cell therapy for tolerance in autoimmunity and solid organ transplantation
title Foxp3+ regulatory T cell therapy for tolerance in autoimmunity and solid organ transplantation
title_full Foxp3+ regulatory T cell therapy for tolerance in autoimmunity and solid organ transplantation
title_fullStr Foxp3+ regulatory T cell therapy for tolerance in autoimmunity and solid organ transplantation
title_full_unstemmed Foxp3+ regulatory T cell therapy for tolerance in autoimmunity and solid organ transplantation
title_short Foxp3+ regulatory T cell therapy for tolerance in autoimmunity and solid organ transplantation
title_sort foxp3+ regulatory t cell therapy for tolerance in autoimmunity and solid organ transplantation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714335/
https://www.ncbi.nlm.nih.gov/pubmed/36466912
http://dx.doi.org/10.3389/fimmu.2022.1055466
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