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Extracellular RNA as a kind of communication molecule and emerging cancer biomarker
Extracellular RNA (exRNA) is a special form of RNA in the body. RNA carries information about genes and metabolic regulation in the body, which can reflect the real-time status of cells. This characteristic renders it a biomarker for disease diagnosis, treatment, and prognosis. ExRNA is transported...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714358/ https://www.ncbi.nlm.nih.gov/pubmed/36465402 http://dx.doi.org/10.3389/fonc.2022.960072 |
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author | Wu, Danny Tao, Tao Eshraghian, Emily A. Lin, Peixu Li, Zesong Zhu, Xiao |
author_facet | Wu, Danny Tao, Tao Eshraghian, Emily A. Lin, Peixu Li, Zesong Zhu, Xiao |
author_sort | Wu, Danny |
collection | PubMed |
description | Extracellular RNA (exRNA) is a special form of RNA in the body. RNA carries information about genes and metabolic regulation in the body, which can reflect the real-time status of cells. This characteristic renders it a biomarker for disease diagnosis, treatment, and prognosis. ExRNA is transported through extracellular vesicles as a signal medium to mediate communication between cells. Tumor cells can release more vesicles than normal cells, thereby promoting tumor development. Depending on its easy detection, the advantages of non-invasive molecular diagnostic technology can be realized. In this systematic review, we present the types, vectors, and biological value of exRNA. We briefly describe new methods of tumor diagnosis and treatment, as well as the difficulties faced in the progress of such research. This review highlights the groundbreaking potential of exRNA as a clinical biomarker. |
format | Online Article Text |
id | pubmed-9714358 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97143582022-12-02 Extracellular RNA as a kind of communication molecule and emerging cancer biomarker Wu, Danny Tao, Tao Eshraghian, Emily A. Lin, Peixu Li, Zesong Zhu, Xiao Front Oncol Oncology Extracellular RNA (exRNA) is a special form of RNA in the body. RNA carries information about genes and metabolic regulation in the body, which can reflect the real-time status of cells. This characteristic renders it a biomarker for disease diagnosis, treatment, and prognosis. ExRNA is transported through extracellular vesicles as a signal medium to mediate communication between cells. Tumor cells can release more vesicles than normal cells, thereby promoting tumor development. Depending on its easy detection, the advantages of non-invasive molecular diagnostic technology can be realized. In this systematic review, we present the types, vectors, and biological value of exRNA. We briefly describe new methods of tumor diagnosis and treatment, as well as the difficulties faced in the progress of such research. This review highlights the groundbreaking potential of exRNA as a clinical biomarker. Frontiers Media S.A. 2022-11-17 /pmc/articles/PMC9714358/ /pubmed/36465402 http://dx.doi.org/10.3389/fonc.2022.960072 Text en Copyright © 2022 Wu, Tao, Eshraghian, Lin, Li and Zhu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Wu, Danny Tao, Tao Eshraghian, Emily A. Lin, Peixu Li, Zesong Zhu, Xiao Extracellular RNA as a kind of communication molecule and emerging cancer biomarker |
title | Extracellular RNA as a kind of communication molecule and emerging cancer biomarker |
title_full | Extracellular RNA as a kind of communication molecule and emerging cancer biomarker |
title_fullStr | Extracellular RNA as a kind of communication molecule and emerging cancer biomarker |
title_full_unstemmed | Extracellular RNA as a kind of communication molecule and emerging cancer biomarker |
title_short | Extracellular RNA as a kind of communication molecule and emerging cancer biomarker |
title_sort | extracellular rna as a kind of communication molecule and emerging cancer biomarker |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714358/ https://www.ncbi.nlm.nih.gov/pubmed/36465402 http://dx.doi.org/10.3389/fonc.2022.960072 |
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