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Extracellular RNA as a kind of communication molecule and emerging cancer biomarker

Extracellular RNA (exRNA) is a special form of RNA in the body. RNA carries information about genes and metabolic regulation in the body, which can reflect the real-time status of cells. This characteristic renders it a biomarker for disease diagnosis, treatment, and prognosis. ExRNA is transported...

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Autores principales: Wu, Danny, Tao, Tao, Eshraghian, Emily A., Lin, Peixu, Li, Zesong, Zhu, Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714358/
https://www.ncbi.nlm.nih.gov/pubmed/36465402
http://dx.doi.org/10.3389/fonc.2022.960072
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author Wu, Danny
Tao, Tao
Eshraghian, Emily A.
Lin, Peixu
Li, Zesong
Zhu, Xiao
author_facet Wu, Danny
Tao, Tao
Eshraghian, Emily A.
Lin, Peixu
Li, Zesong
Zhu, Xiao
author_sort Wu, Danny
collection PubMed
description Extracellular RNA (exRNA) is a special form of RNA in the body. RNA carries information about genes and metabolic regulation in the body, which can reflect the real-time status of cells. This characteristic renders it a biomarker for disease diagnosis, treatment, and prognosis. ExRNA is transported through extracellular vesicles as a signal medium to mediate communication between cells. Tumor cells can release more vesicles than normal cells, thereby promoting tumor development. Depending on its easy detection, the advantages of non-invasive molecular diagnostic technology can be realized. In this systematic review, we present the types, vectors, and biological value of exRNA. We briefly describe new methods of tumor diagnosis and treatment, as well as the difficulties faced in the progress of such research. This review highlights the groundbreaking potential of exRNA as a clinical biomarker.
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spelling pubmed-97143582022-12-02 Extracellular RNA as a kind of communication molecule and emerging cancer biomarker Wu, Danny Tao, Tao Eshraghian, Emily A. Lin, Peixu Li, Zesong Zhu, Xiao Front Oncol Oncology Extracellular RNA (exRNA) is a special form of RNA in the body. RNA carries information about genes and metabolic regulation in the body, which can reflect the real-time status of cells. This characteristic renders it a biomarker for disease diagnosis, treatment, and prognosis. ExRNA is transported through extracellular vesicles as a signal medium to mediate communication between cells. Tumor cells can release more vesicles than normal cells, thereby promoting tumor development. Depending on its easy detection, the advantages of non-invasive molecular diagnostic technology can be realized. In this systematic review, we present the types, vectors, and biological value of exRNA. We briefly describe new methods of tumor diagnosis and treatment, as well as the difficulties faced in the progress of such research. This review highlights the groundbreaking potential of exRNA as a clinical biomarker. Frontiers Media S.A. 2022-11-17 /pmc/articles/PMC9714358/ /pubmed/36465402 http://dx.doi.org/10.3389/fonc.2022.960072 Text en Copyright © 2022 Wu, Tao, Eshraghian, Lin, Li and Zhu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wu, Danny
Tao, Tao
Eshraghian, Emily A.
Lin, Peixu
Li, Zesong
Zhu, Xiao
Extracellular RNA as a kind of communication molecule and emerging cancer biomarker
title Extracellular RNA as a kind of communication molecule and emerging cancer biomarker
title_full Extracellular RNA as a kind of communication molecule and emerging cancer biomarker
title_fullStr Extracellular RNA as a kind of communication molecule and emerging cancer biomarker
title_full_unstemmed Extracellular RNA as a kind of communication molecule and emerging cancer biomarker
title_short Extracellular RNA as a kind of communication molecule and emerging cancer biomarker
title_sort extracellular rna as a kind of communication molecule and emerging cancer biomarker
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714358/
https://www.ncbi.nlm.nih.gov/pubmed/36465402
http://dx.doi.org/10.3389/fonc.2022.960072
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