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Characterisation of a common hotspot variant in acute intermittent porphyria sheds light on the mechanism of hydroxymethylbilane synthase function

Hydroxymethylbilane synthase (HMBS) is the third enzyme involved in haem biosynthesis, in which it catalyses the formation of tetrapyrrole 1‐hydroxymethylbilane (HMB). In this process, HMBS binds four consecutive substrate molecules, creating the enzyme‐intermediate complexes ES, ES(2), ES(3) and ES...

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Detalles Bibliográficos
Autores principales:	Christie, Marthe S., Laitaoja, Mikko, Aarsand, Aasne K., Kallio, Juha P., Bustad, Helene J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714363/ https://www.ncbi.nlm.nih.gov/pubmed/36115019 http://dx.doi.org/10.1002/2211-5463.13490

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