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A missing link in affect regulation: the cerebellum
The cerebellum is one-third the size of the cerebrum yet holds twice the number of neurons. Historically, its sole function was thought to be in the calibration of smooth movements through the creation and ongoing modification of motor programs. This traditional viewpoint has been challenged by find...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714429/ https://www.ncbi.nlm.nih.gov/pubmed/35733348 http://dx.doi.org/10.1093/scan/nsac042 |
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author | Frazier, Madeleine R Hoffman, Linda J Popal, Haroon Sullivan-Toole, Holly Olino, Thomas M Olson, Ingrid R |
author_facet | Frazier, Madeleine R Hoffman, Linda J Popal, Haroon Sullivan-Toole, Holly Olino, Thomas M Olson, Ingrid R |
author_sort | Frazier, Madeleine R |
collection | PubMed |
description | The cerebellum is one-third the size of the cerebrum yet holds twice the number of neurons. Historically, its sole function was thought to be in the calibration of smooth movements through the creation and ongoing modification of motor programs. This traditional viewpoint has been challenged by findings showing that cerebellar damage can lead to striking changes in non-motor behavior, including emotional changes. In this manuscript, we review the literature on clinical and subclinical affective disturbances observed in individuals with lesions to the cerebellum. Disorders include pathological laughing and crying, bipolar disorder, depression and mixed mood changes. We propose a theoretical model based on cerebellar connectivity to explain how the cerebellum calibrates affect. We conclude with actionable steps for future researchers to test this model and improve upon the limitations of past literature. |
format | Online Article Text |
id | pubmed-9714429 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-97144292022-12-02 A missing link in affect regulation: the cerebellum Frazier, Madeleine R Hoffman, Linda J Popal, Haroon Sullivan-Toole, Holly Olino, Thomas M Olson, Ingrid R Soc Cogn Affect Neurosci Original Manuscript The cerebellum is one-third the size of the cerebrum yet holds twice the number of neurons. Historically, its sole function was thought to be in the calibration of smooth movements through the creation and ongoing modification of motor programs. This traditional viewpoint has been challenged by findings showing that cerebellar damage can lead to striking changes in non-motor behavior, including emotional changes. In this manuscript, we review the literature on clinical and subclinical affective disturbances observed in individuals with lesions to the cerebellum. Disorders include pathological laughing and crying, bipolar disorder, depression and mixed mood changes. We propose a theoretical model based on cerebellar connectivity to explain how the cerebellum calibrates affect. We conclude with actionable steps for future researchers to test this model and improve upon the limitations of past literature. Oxford University Press 2022-06-22 /pmc/articles/PMC9714429/ /pubmed/35733348 http://dx.doi.org/10.1093/scan/nsac042 Text en © The Author(s) 2022. Published by Oxford University Press. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Original Manuscript Frazier, Madeleine R Hoffman, Linda J Popal, Haroon Sullivan-Toole, Holly Olino, Thomas M Olson, Ingrid R A missing link in affect regulation: the cerebellum |
title | A missing link in affect regulation: the cerebellum |
title_full | A missing link in affect regulation: the cerebellum |
title_fullStr | A missing link in affect regulation: the cerebellum |
title_full_unstemmed | A missing link in affect regulation: the cerebellum |
title_short | A missing link in affect regulation: the cerebellum |
title_sort | missing link in affect regulation: the cerebellum |
topic | Original Manuscript |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714429/ https://www.ncbi.nlm.nih.gov/pubmed/35733348 http://dx.doi.org/10.1093/scan/nsac042 |
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