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Case report: Minimal manifestations of mucous membrane pemphigoid in a young adult
A male patient presented to our department at the age of 23 suffering from recurrent painful erosions in the urethral outlet area. In closer clinical examination gingival erosions, primarily around the teeth were identified as well. Indirect immunofluorescence on salt split skin with epidermal IgG d...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714672/ https://www.ncbi.nlm.nih.gov/pubmed/36465929 http://dx.doi.org/10.3389/fmed.2022.1052145 |
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author | Schauer, Franziska Casetti, Federica Kiritsi, Dimitra |
author_facet | Schauer, Franziska Casetti, Federica Kiritsi, Dimitra |
author_sort | Schauer, Franziska |
collection | PubMed |
description | A male patient presented to our department at the age of 23 suffering from recurrent painful erosions in the urethral outlet area. In closer clinical examination gingival erosions, primarily around the teeth were identified as well. Indirect immunofluorescence on salt split skin with epidermal IgG deposition and positive anti-BP230 IgG ELISA diagnostics hinted toward the presence of mucous membrane pemphigoid (MMP). Direct immunofluorescence from oral mucosa confirmed the diagnosis. MMP in young adulthood is an underdiagnosed disease and latency of diagnosis was around 4 years in our case. Treatment with systemic glucocorticosteroids and dapsone led to clinical remission, prohibiting the development of MMP manifestations in further organs and complications associated with the disease, e.g., scar formation and miction problems. |
format | Online Article Text |
id | pubmed-9714672 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97146722022-12-02 Case report: Minimal manifestations of mucous membrane pemphigoid in a young adult Schauer, Franziska Casetti, Federica Kiritsi, Dimitra Front Med (Lausanne) Medicine A male patient presented to our department at the age of 23 suffering from recurrent painful erosions in the urethral outlet area. In closer clinical examination gingival erosions, primarily around the teeth were identified as well. Indirect immunofluorescence on salt split skin with epidermal IgG deposition and positive anti-BP230 IgG ELISA diagnostics hinted toward the presence of mucous membrane pemphigoid (MMP). Direct immunofluorescence from oral mucosa confirmed the diagnosis. MMP in young adulthood is an underdiagnosed disease and latency of diagnosis was around 4 years in our case. Treatment with systemic glucocorticosteroids and dapsone led to clinical remission, prohibiting the development of MMP manifestations in further organs and complications associated with the disease, e.g., scar formation and miction problems. Frontiers Media S.A. 2022-11-17 /pmc/articles/PMC9714672/ /pubmed/36465929 http://dx.doi.org/10.3389/fmed.2022.1052145 Text en Copyright © 2022 Schauer, Casetti and Kiritsi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Schauer, Franziska Casetti, Federica Kiritsi, Dimitra Case report: Minimal manifestations of mucous membrane pemphigoid in a young adult |
title | Case report: Minimal manifestations of mucous membrane pemphigoid in a young adult |
title_full | Case report: Minimal manifestations of mucous membrane pemphigoid in a young adult |
title_fullStr | Case report: Minimal manifestations of mucous membrane pemphigoid in a young adult |
title_full_unstemmed | Case report: Minimal manifestations of mucous membrane pemphigoid in a young adult |
title_short | Case report: Minimal manifestations of mucous membrane pemphigoid in a young adult |
title_sort | case report: minimal manifestations of mucous membrane pemphigoid in a young adult |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714672/ https://www.ncbi.nlm.nih.gov/pubmed/36465929 http://dx.doi.org/10.3389/fmed.2022.1052145 |
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