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Using inflammatory index to distinguish asthma, asthma-COPD overlap and COPD: A retrospective observational study

BACKGROUND: Although asthma and chronic obstructive pulmonary disease (COPD) are two well-defined and distinct diseases, some patients present combined clinical features of both asthma and COPD, particularly in smokers and the elderly, a condition termed as asthma-COPD overlap (ACO). However, the de...

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Autores principales: Ma, Haiman, Yang, Liu, Liu, Lingli, Zhou, Ying, Guo, Xiaoya, Wu, Shuo, Zhang, Xiaoxiao, Xu, Xi, Ti, Xinyu, Qu, Shuoyao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714673/
https://www.ncbi.nlm.nih.gov/pubmed/36465915
http://dx.doi.org/10.3389/fmed.2022.1045503
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author Ma, Haiman
Yang, Liu
Liu, Lingli
Zhou, Ying
Guo, Xiaoya
Wu, Shuo
Zhang, Xiaoxiao
Xu, Xi
Ti, Xinyu
Qu, Shuoyao
author_facet Ma, Haiman
Yang, Liu
Liu, Lingli
Zhou, Ying
Guo, Xiaoya
Wu, Shuo
Zhang, Xiaoxiao
Xu, Xi
Ti, Xinyu
Qu, Shuoyao
author_sort Ma, Haiman
collection PubMed
description BACKGROUND: Although asthma and chronic obstructive pulmonary disease (COPD) are two well-defined and distinct diseases, some patients present combined clinical features of both asthma and COPD, particularly in smokers and the elderly, a condition termed as asthma-COPD overlap (ACO). However, the definition of ACO is yet to be established and clinical guidelines to identify and manage ACO remain controversial. Therefore, in this study, inflammatory biomarkers were established to distinguish asthma, ACO, and COPD, and their relationship with the severity of patients’ symptoms and pulmonary function were explored. MATERIALS AND METHODS: A total of 178 patients, diagnosed with asthma (n = 38), ACO (n = 44), and COPD (n = 96) between January 2021 to June 2022, were enrolled in this study. The patients’ pulmonary function was examined and routine blood samples were taken for the analysis of inflammatory indexes. Logistic regression analysis was used to establish inflammatory biomarkers for distinguishing asthma, ACO, and COPD; linear regression analysis was used to analyze the relationship between inflammatory indexes and symptom severity and pulmonary function. RESULT: The results showed that, compared with ACO, the higher the indexes of platelet, neutrophil-lymphocyte ratio (NLR) and eosinophil-basophil ratio (EBR), the more likely the possibility of asthma and COPD in patients, while the higher the eosinophils, the less likely the possibility of asthma and COPD. Hemoglobin and lymphocyte-monocyte ratio (LMR) were negatively correlated with the severity of patients’ symptoms, while platelet-lymphocyte ratio (PLR) was negatively correlated with forced expiratory volume in the 1 s/forced vital capacity (FEV(1)/FVC) and FEV(1) percent predicted (% pred), and EBR was positively correlated with FEV(1%) pred. CONCLUSION: Inflammatory indexes are biomarkers for distinguishing asthma, ACO, and COPD, which are of clinical significance in therapeutic strategies and prognosis evaluation.
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spelling pubmed-97146732022-12-02 Using inflammatory index to distinguish asthma, asthma-COPD overlap and COPD: A retrospective observational study Ma, Haiman Yang, Liu Liu, Lingli Zhou, Ying Guo, Xiaoya Wu, Shuo Zhang, Xiaoxiao Xu, Xi Ti, Xinyu Qu, Shuoyao Front Med (Lausanne) Medicine BACKGROUND: Although asthma and chronic obstructive pulmonary disease (COPD) are two well-defined and distinct diseases, some patients present combined clinical features of both asthma and COPD, particularly in smokers and the elderly, a condition termed as asthma-COPD overlap (ACO). However, the definition of ACO is yet to be established and clinical guidelines to identify and manage ACO remain controversial. Therefore, in this study, inflammatory biomarkers were established to distinguish asthma, ACO, and COPD, and their relationship with the severity of patients’ symptoms and pulmonary function were explored. MATERIALS AND METHODS: A total of 178 patients, diagnosed with asthma (n = 38), ACO (n = 44), and COPD (n = 96) between January 2021 to June 2022, were enrolled in this study. The patients’ pulmonary function was examined and routine blood samples were taken for the analysis of inflammatory indexes. Logistic regression analysis was used to establish inflammatory biomarkers for distinguishing asthma, ACO, and COPD; linear regression analysis was used to analyze the relationship between inflammatory indexes and symptom severity and pulmonary function. RESULT: The results showed that, compared with ACO, the higher the indexes of platelet, neutrophil-lymphocyte ratio (NLR) and eosinophil-basophil ratio (EBR), the more likely the possibility of asthma and COPD in patients, while the higher the eosinophils, the less likely the possibility of asthma and COPD. Hemoglobin and lymphocyte-monocyte ratio (LMR) were negatively correlated with the severity of patients’ symptoms, while platelet-lymphocyte ratio (PLR) was negatively correlated with forced expiratory volume in the 1 s/forced vital capacity (FEV(1)/FVC) and FEV(1) percent predicted (% pred), and EBR was positively correlated with FEV(1%) pred. CONCLUSION: Inflammatory indexes are biomarkers for distinguishing asthma, ACO, and COPD, which are of clinical significance in therapeutic strategies and prognosis evaluation. Frontiers Media S.A. 2022-11-17 /pmc/articles/PMC9714673/ /pubmed/36465915 http://dx.doi.org/10.3389/fmed.2022.1045503 Text en Copyright © 2022 Ma, Yang, Liu, Zhou, Guo, Wu, Zhang, Xu, Ti and Qu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Ma, Haiman
Yang, Liu
Liu, Lingli
Zhou, Ying
Guo, Xiaoya
Wu, Shuo
Zhang, Xiaoxiao
Xu, Xi
Ti, Xinyu
Qu, Shuoyao
Using inflammatory index to distinguish asthma, asthma-COPD overlap and COPD: A retrospective observational study
title Using inflammatory index to distinguish asthma, asthma-COPD overlap and COPD: A retrospective observational study
title_full Using inflammatory index to distinguish asthma, asthma-COPD overlap and COPD: A retrospective observational study
title_fullStr Using inflammatory index to distinguish asthma, asthma-COPD overlap and COPD: A retrospective observational study
title_full_unstemmed Using inflammatory index to distinguish asthma, asthma-COPD overlap and COPD: A retrospective observational study
title_short Using inflammatory index to distinguish asthma, asthma-COPD overlap and COPD: A retrospective observational study
title_sort using inflammatory index to distinguish asthma, asthma-copd overlap and copd: a retrospective observational study
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714673/
https://www.ncbi.nlm.nih.gov/pubmed/36465915
http://dx.doi.org/10.3389/fmed.2022.1045503
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