Cargando…
Vascular responses of penetrating vessels during cortical spreading depolarization with ultrasound dynamic ultrafast Doppler imaging
The dynamic vascular responses during cortical spreading depolarization (CSD) are causally related to pathophysiological consequences in numerous neurovascular conditions, including ischemia, traumatic brain injury, cerebral hemorrhage, and migraine. Monitoring of the hemodynamic responses of cerebr...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714680/ https://www.ncbi.nlm.nih.gov/pubmed/36466181 http://dx.doi.org/10.3389/fnins.2022.1015843 |
_version_ | 1784842280191918080 |
---|---|
author | Hsieh, Bao-Yu Kao, Yu-Chieh Jill Zhou, Ning Lin, Yi-Pei Mei, Yu-Ying Chu, Sung-Yu Wu, Dong-Chuan |
author_facet | Hsieh, Bao-Yu Kao, Yu-Chieh Jill Zhou, Ning Lin, Yi-Pei Mei, Yu-Ying Chu, Sung-Yu Wu, Dong-Chuan |
author_sort | Hsieh, Bao-Yu |
collection | PubMed |
description | The dynamic vascular responses during cortical spreading depolarization (CSD) are causally related to pathophysiological consequences in numerous neurovascular conditions, including ischemia, traumatic brain injury, cerebral hemorrhage, and migraine. Monitoring of the hemodynamic responses of cerebral penetrating vessels during CSD is motivated to understand the mechanism of CSD and related neurological disorders. Six SD rats were used, and craniotomy surgery was performed before imaging. CSDs were induced by topical KCl application. Ultrasound dynamic ultrafast Doppler was used to access hemodynamic changes, including cerebral blood volume (CBV) and flow velocity during CSD, and further analyzed those in a single penetrating arteriole or venule. The CSD-induced hemodynamic changes with typical duration and propagation speed were detected by ultrafast Doppler in the cerebral cortex ipsilateral to the induction site. The hemodynamics typically showed triphasic changes, including initial hypoperfusion and prominent hyperperfusion peak, followed by a long-period depression in CBV. Moreover, different hemodynamics between individual penetrating arterioles and venules were proposed by quantification of CBV and flow velocity. The negative correlation between the basal CBV and CSD-induced change was also reported in penetrating vessels. These results indicate specific vascular dynamics of cerebral penetrating vessels and possibly different contributions of penetrating arterioles and venules to the CSD-related pathological vascular consequences. We proposed using ultrasound dynamic ultrafast Doppler imaging to investigate CSD-induced cerebral vascular responses. With this imaging platform, it has the potential to monitor the hemodynamics of cortical penetrating vessels during brain injuries to understand the mechanism of CSD in advance. |
format | Online Article Text |
id | pubmed-9714680 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97146802022-12-02 Vascular responses of penetrating vessels during cortical spreading depolarization with ultrasound dynamic ultrafast Doppler imaging Hsieh, Bao-Yu Kao, Yu-Chieh Jill Zhou, Ning Lin, Yi-Pei Mei, Yu-Ying Chu, Sung-Yu Wu, Dong-Chuan Front Neurosci Neuroscience The dynamic vascular responses during cortical spreading depolarization (CSD) are causally related to pathophysiological consequences in numerous neurovascular conditions, including ischemia, traumatic brain injury, cerebral hemorrhage, and migraine. Monitoring of the hemodynamic responses of cerebral penetrating vessels during CSD is motivated to understand the mechanism of CSD and related neurological disorders. Six SD rats were used, and craniotomy surgery was performed before imaging. CSDs were induced by topical KCl application. Ultrasound dynamic ultrafast Doppler was used to access hemodynamic changes, including cerebral blood volume (CBV) and flow velocity during CSD, and further analyzed those in a single penetrating arteriole or venule. The CSD-induced hemodynamic changes with typical duration and propagation speed were detected by ultrafast Doppler in the cerebral cortex ipsilateral to the induction site. The hemodynamics typically showed triphasic changes, including initial hypoperfusion and prominent hyperperfusion peak, followed by a long-period depression in CBV. Moreover, different hemodynamics between individual penetrating arterioles and venules were proposed by quantification of CBV and flow velocity. The negative correlation between the basal CBV and CSD-induced change was also reported in penetrating vessels. These results indicate specific vascular dynamics of cerebral penetrating vessels and possibly different contributions of penetrating arterioles and venules to the CSD-related pathological vascular consequences. We proposed using ultrasound dynamic ultrafast Doppler imaging to investigate CSD-induced cerebral vascular responses. With this imaging platform, it has the potential to monitor the hemodynamics of cortical penetrating vessels during brain injuries to understand the mechanism of CSD in advance. Frontiers Media S.A. 2022-11-16 /pmc/articles/PMC9714680/ /pubmed/36466181 http://dx.doi.org/10.3389/fnins.2022.1015843 Text en Copyright © 2022 Hsieh, Kao, Zhou, Lin, Mei, Chu and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Hsieh, Bao-Yu Kao, Yu-Chieh Jill Zhou, Ning Lin, Yi-Pei Mei, Yu-Ying Chu, Sung-Yu Wu, Dong-Chuan Vascular responses of penetrating vessels during cortical spreading depolarization with ultrasound dynamic ultrafast Doppler imaging |
title | Vascular responses of penetrating vessels during cortical spreading depolarization with ultrasound dynamic ultrafast Doppler imaging |
title_full | Vascular responses of penetrating vessels during cortical spreading depolarization with ultrasound dynamic ultrafast Doppler imaging |
title_fullStr | Vascular responses of penetrating vessels during cortical spreading depolarization with ultrasound dynamic ultrafast Doppler imaging |
title_full_unstemmed | Vascular responses of penetrating vessels during cortical spreading depolarization with ultrasound dynamic ultrafast Doppler imaging |
title_short | Vascular responses of penetrating vessels during cortical spreading depolarization with ultrasound dynamic ultrafast Doppler imaging |
title_sort | vascular responses of penetrating vessels during cortical spreading depolarization with ultrasound dynamic ultrafast doppler imaging |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714680/ https://www.ncbi.nlm.nih.gov/pubmed/36466181 http://dx.doi.org/10.3389/fnins.2022.1015843 |
work_keys_str_mv | AT hsiehbaoyu vascularresponsesofpenetratingvesselsduringcorticalspreadingdepolarizationwithultrasounddynamicultrafastdopplerimaging AT kaoyuchiehjill vascularresponsesofpenetratingvesselsduringcorticalspreadingdepolarizationwithultrasounddynamicultrafastdopplerimaging AT zhouning vascularresponsesofpenetratingvesselsduringcorticalspreadingdepolarizationwithultrasounddynamicultrafastdopplerimaging AT linyipei vascularresponsesofpenetratingvesselsduringcorticalspreadingdepolarizationwithultrasounddynamicultrafastdopplerimaging AT meiyuying vascularresponsesofpenetratingvesselsduringcorticalspreadingdepolarizationwithultrasounddynamicultrafastdopplerimaging AT chusungyu vascularresponsesofpenetratingvesselsduringcorticalspreadingdepolarizationwithultrasounddynamicultrafastdopplerimaging AT wudongchuan vascularresponsesofpenetratingvesselsduringcorticalspreadingdepolarizationwithultrasounddynamicultrafastdopplerimaging |