Evaluation of the acute oral toxicity and antipsychotic activity of a dual inhibitor of PDE1B and PDE10A in rat model of schizophrenia

Phosphodiesterase 1B (PDE1B) and PDE10A are dual-specificity PDEs that hydrolyse both cyclic adenosine monophosphate and cyclic guanosine monophosphate, and are highly expressed in the striatum. Several reports have suggested that PDE10A inhibitors may present a promising approach for the treatment...

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Detalles Bibliográficos
Autores principales: Al-Nema, Mayasah, Gaurav, Anand, Lee, Ming Tatt, Okechukwu, Patrick, Nimmanpipug, Piyarat, Lee, Vannajan Sanghiran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714703/
https://www.ncbi.nlm.nih.gov/pubmed/36454774
http://dx.doi.org/10.1371/journal.pone.0278216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714703/
https://www.ncbi.nlm.nih.gov/pubmed/36454774
http://dx.doi.org/10.1371/journal.pone.0278216

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