Neutrophil degranulation, NETosis and platelet degranulation pathway genes are co-induced in whole blood up to six months before tuberculosis diagnosis

Mycobacterium tuberculosis (M.tb) causes tuberculosis (TB) and remains one of the leading causes of mortality due to an infectious pathogen. Host immune responses have been implicated in driving the progression from infection to severe lung disease. We analyzed longitudinal RNA sequencing (RNAseq) d...

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Detalles Bibliográficos
Autores principales: Meier, Stuart, Seddon, James A., Maasdorp, Elizna, Kleynhans, Léanie, du Plessis, Nelita, Loxton, Andre G., Malherbe, Stephanus T., Zak, Daniel E., Thompson, Ethan, Duffy, Fergal J., Kaufmann, Stefan H. E., Ottenhoff, Tom H. M., Scriba, Thomas J., Suliman, Sara, Sutherland, Jayne S., Winter, Jill, Kuivaniemi, Helena, Walzl, Gerhard, Tromp, Gerard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714760/
https://www.ncbi.nlm.nih.gov/pubmed/36454773
http://dx.doi.org/10.1371/journal.pone.0278295

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