PRC2 loss drives MPNST metastasis and matrix remodeling

The histone methyltransferase PRC2 plays a complex role in cancer. Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas with frequent loss-of-function mutations in PRC2 that are associated with poor outcome. Here, we identify a critical role for PRC2 loss in driving MPNST metast...

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Detalles Bibliográficos
Autores principales: Brockman, Qierra R., Scherer, Amanda, McGivney, Gavin R., Gutierrez, Wade R., Voigt, Andrew P., Isaacson, Alexandra L., Laverty, Emily A., Roughton, Grace, Knepper-Adrian, Vickie, Darbro, Benjamin, Tanas, Munir R., Stipp, Christopher S., Dodd, Rebecca D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714789/
https://www.ncbi.nlm.nih.gov/pubmed/36066973
http://dx.doi.org/10.1172/jci.insight.157502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714789/
https://www.ncbi.nlm.nih.gov/pubmed/36066973
http://dx.doi.org/10.1172/jci.insight.157502

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