Cargando…

PRC2 loss drives MPNST metastasis and matrix remodeling

The histone methyltransferase PRC2 plays a complex role in cancer. Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas with frequent loss-of-function mutations in PRC2 that are associated with poor outcome. Here, we identify a critical role for PRC2 loss in driving MPNST metast...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brockman, Qierra R., Scherer, Amanda, McGivney, Gavin R., Gutierrez, Wade R., Voigt, Andrew P., Isaacson, Alexandra L., Laverty, Emily A., Roughton, Grace, Knepper-Adrian, Vickie, Darbro, Benjamin, Tanas, Munir R., Stipp, Christopher S., Dodd, Rebecca D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714789/ https://www.ncbi.nlm.nih.gov/pubmed/36066973 http://dx.doi.org/10.1172/jci.insight.157502

Ejemplares similares

Divergent immune landscapes of primary and syngeneic Kras-driven mouse tumor models
por: Gutierrez, Wade R., et al.
Publicado: (2021)

Discrepancies in indel software resolution with somatic CRISPR/Cas9 tumorigenesis models
por: Brockman, Qierra R., et al.
Publicado: (2023)

Loss of Nf1 and Ink4a/Arf Are Associated with Sex-Dependent Growth Differences in a Mouse Model of Embryonal Rhabdomyosarcoma
por: Gutierrez, Wade R., et al.
Publicado: (2023)

Augmenting chemotherapy with low-dose decitabine through an immune-independent mechanism
por: Gutierrez, Wade R., et al.
Publicado: (2022)

Oncogenic RABL6A promotes NF1-associated MPNST progression in vivo
por: Kohlmeyer, Jordan L, et al.
Publicado: (2022)

Distinct Tumor Microenvironments Are a Defining Feature of Strain-Specific CRISPR/Cas9-Induced MPNSTs
por: Scherer, Amanda, et al.
Publicado: (2020)

Epigenetic modulation in sensitizing metastatic sarcomas to therapies and overcoming resistance
por: Rytlewski, Jeff, et al.
Publicado: (2022)

Metallosis, psoas abscess and infected hip prosthesis in a patient with bilateral metal on metal total hip replacement
por: Rymaruk, S, et al.
Publicado: (2012)

SHH PATHWAY ACTIVATION IN DEDIFFERENTIATION DURING TUMOR PROGRESSION IN MPNST
por: Yakubov, R Y, et al.
Publicado: (2023)

BCRP expression in schwannoma, plexiform neurofibroma and MPNST
por: de Vries, Maurits, et al.
Publicado: (2017)

Combination therapies for MPNSTs targeting RABL6A-RB1 signaling
por: Kohlmeyer, Jordan L., et al.
Publicado: (2021)

McCracken, prótesis parcial removible
por: McGivney, Glen P.
Publicado: (2004)

McCracken, prótesis parcial removible
por: McGivney, Glen P.
Publicado: (1992)

Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST
por: Keng, Vincent W., et al.
Publicado: (2012)

Factors Within the Endoneurial Microenvironment Act to Suppress Tumorigenesis of MPNST
por: Stratton, Jo Anne, et al.
Publicado: (2018)

Chromosome 8 gain is associated with high-grade transformation in MPNST
por: Dehner, Carina, et al.
Publicado: (2021)

Malignant transformation of plexiform neurofibroma to MPNST while on MEK inhibitor
por: Fasih, Samir, et al.
Publicado: (2021)

Chimeric antigen receptor T cell therapies for multiple myeloma
por: Wu, Chao, et al.
Publicado: (2019)

Unmasking Intra-Tumoral Heterogeneity and Clonal Evolution in NF1-MPNST
por: Moon, Chang-In, et al.
Publicado: (2020)

Neurofibromatosis Type 1–Associated MPNST State of the Science: Outlining a Research Agenda for the Future
por: Reilly, Karlyne M., et al.
Publicado: (2017)

Evaluation of microRNA expression in plasma and skeletal muscle of thoroughbred racehorses in training
por: McGivney, B. A., et al.
Publicado: (2017)

A dimeric state for PRC2
por: Davidovich, Chen, et al.
Publicado: (2014)

Stakeholder-Guided Formation of a Statewide Community Pharmacy Practice-Based Research Network
por: Carroll, Joni C., et al.
Publicado: (2019)

Monozygotic twins with Neurofibromatosis type 1, concordant phenotype and synchronous development of MPNST and metastasis
por: Melean, German, et al.
Publicado: (2010)

Survivin Expression and Prognostic Significance in Pediatric Malignant Peripheral Nerve Sheath Tumors (MPNST)
por: Alaggio, Rita, et al.
Publicado: (2013)

CK2 blockade causes MPNST cell apoptosis and promotes degradation of β-catenin
por: Kendall, Jed J., et al.
Publicado: (2016)

Aberrant ATRX protein expression is associated with poor overall survival in NF1-MPNST
por: Lu, Hsiang-Chih, et al.
Publicado: (2018)

NFB-01. FUNCTIONAL CHARACTERIZATION OF ATRX LOSS IN NF1-ASSOCIATED GLIOMA AND MPNST
por: Yuan, Ming, et al.
Publicado: (2020)

Plexiform malignant peripheral nerve sheath tumor(MPNST) in infancy and childhood--a case report.
por: Nam, E. S., et al.
Publicado: (1994)

Correction: Aberrant ATRX protein expression is associated with poor overall survival in NF1-MPNST
por: Lu, Hsiang-Chih, et al.
Publicado: (2021)

Equine skeletal muscle adaptations to exercise and training: evidence of differential regulation of autophagosomal and mitochondrial components
por: Bryan, Kenneth, et al.
Publicado: (2017)

Regulation of histone methylation by automethylation of PRC2
por: Wang, Xueyin, et al.
Publicado: (2019)

Interdependence of PRC1 and PRC2 for recruitment to Polycomb Response Elements
por: Kahn, Tatyana G., et al.
Publicado: (2016)

PRC1 preserves epidermal tissue integrity independently of PRC2
por: Cohen, Idan, et al.
Publicado: (2019)

Independent domains for recruitment of PRC1 and PRC2 by human XIST
por: Dixon-McDougall, Thomas, et al.
Publicado: (2021)

Structure and Function of the Polycomb Repressive Complexes PRC1 and PRC2
por: Angrand, Pierre-Olivier
Publicado: (2022)

Parallel PRC2/cPRC1 and vPRC1 pathways silence lineage-specific genes and maintain self-renewal in mouse embryonic stem cells
por: Zepeda-Martinez, J. A., et al.
Publicado: (2020)

Malignant neuroectodermal tumor with melanocytic and rhabdomyoblastic differentiation
por: Tanas, Munir R, et al.
Publicado: (2009)

PRC2.1- and PRC2.2-specific accessory proteins drive recruitment of different forms of canonical PRC1
por: Glancy, Eleanor, et al.
Publicado: (2023)

PRC1 and PRC2 Are Not Required for Targeting of H2A.Z to Developmental Genes in Embryonic Stem Cells
por: Illingworth, Robert S., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_cn7ftnae2c8phlvkc5hul7olp9