Simultaneous separation of naproxen and 6-O-desmethylnaproxen metabolite in saliva samples by liquid chromatography-tandem mass spectrometry: Pharmacokinetic study of naproxen alone and associated with esomeprazol—Results

After performing liquid-liquid extraction with ethyl acetate and HCl, samples from 12 volunteers who performed sequential collections after taking a tablet of naproxen alone (n = 6) or associated with esomeprazole (n = 6) were analyzed in a triple quadrupole mass spectrometer 8040 LC MS/MS Shimadzu....

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Detalles Bibliográficos
Autores principales: Oliveira, Gabriela Moraes, Dionísio, Thiago José, Polanco, Nelson Leonel Del Hierro, Siqueira-Sandrin, Viviane Silva, Faria, Flavio Augusto Cardoso, Santos, Carlos Ferreira, Calvo, Adriana Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714831/
https://www.ncbi.nlm.nih.gov/pubmed/36454922
http://dx.doi.org/10.1371/journal.pone.0278411

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