PNPLA3 allele frequency has no impact on biliary bile acid composition or disease course in patients with primary sclerosing cholangitis

BACKGROUND AND AIMS: Primary sclerosing cholangitis (PSC) is a chronic inflammatory disease that leads to bile duct strictures, cholestasis, and biliary cirrhosis. PNPLA3 (patatin-like phospholipase domain containing 3), regulates cellular lipid synthesis by converting lysophosphatidic acid into pho...

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Detalles Bibliográficos
Autores principales: Färkkilä, Martti, Kautiainen, Hannu, Tenca, Andrea, Jokelainen, Kalle, Arola, Johanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714899/
https://www.ncbi.nlm.nih.gov/pubmed/36454904
http://dx.doi.org/10.1371/journal.pone.0277084

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