Complementary antibody lineages achieve neutralization breadth in an HIV-1 infected elite neutralizer

Broadly neutralizing antibodies (bNAbs) have remarkable breadth and potency against most HIV-1 subtypes and are able to prevent HIV-1 infection in animal models. However, bNAbs are extremely difficult to induce by vaccination. Defining the developmental pathways towards neutralization breadth can as...

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Detalles Bibliográficos
Autores principales: van Schooten, Jelle, Schorcht, Anna, Farokhi, Elinaz, Umotoy, Jeffrey C., Gao, Hongmei, van den Kerkhof, Tom L. G. M., Dorning, Jessica, Rijkhold Meesters, Tim G., van der Woude, Patricia, Burger, Judith A., Bijl, Tom, Ghalaiyini, Riham, Torrents de la Peña, Alba, Turner, Hannah L., Labranche, Celia C., Stanfield, Robyn L., Sok, Devin, Schuitemaker, Hanneke, Montefiori, David C., Burton, Dennis R., Ozorowski, Gabriel, Seaman, Michael S., Wilson, Ian A., Sanders, Rogier W., Ward, Andrew B., van Gils, Marit J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714913/
https://www.ncbi.nlm.nih.gov/pubmed/36395347
http://dx.doi.org/10.1371/journal.ppat.1010945

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