Cargando…
Centrally expressed Cav3.2 T-type calcium channel is critical for the initiation and maintenance of neuropathic pain
Cav3.2 T-type calcium channel is a major molecular actor of neuropathic pain in peripheral sensory neurons, but its involvement at the supraspinal level is almost unknown. In the anterior pretectum (APT), a hub of connectivity of the somatosensory system involved in pain perception, we show that Cav...
Autores principales: | Fayad, Sophie L, Ourties, Guillaume, Le Gac, Benjamin, Jouffre, Baptiste, Lamoine, Sylvain, Fruquière, Antoine, Laffray, Sophie, Gasmi, Laila, Cauli, Bruno, Mallet, Christophe, Bourinet, Emmanuel, Bessaih, Thomas, Lambert, Régis C, Leresche, Nathalie |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714965/ https://www.ncbi.nlm.nih.gov/pubmed/36416409 http://dx.doi.org/10.7554/eLife.79018 |
Ejemplares similares
-
Cav3.2 T-type calcium channels shape electrical firing in mouse Lamina II neurons
por: Candelas, Miriam, et al.
Publicado: (2019) -
T-type calcium channel Ca(v)3.2 deficient mice show elevated anxiety, impaired memory and reduced sensitivity to psychostimulants
por: Gangarossa, Giuseppe, et al.
Publicado: (2014) -
Fxyd2 regulates Aδ- and C-fiber mechanosensitivity and is required for the maintenance of neuropathic pain
por: Ventéo, Stéphanie, et al.
Publicado: (2016) -
The Low-Threshold Calcium Channel Cav3.2 Mediates Burst Firing of Mature Dentate Granule Cells
por: Dumenieu, Mael, et al.
Publicado: (2018) -
Small organic molecule disruptors of Cav3.2 - USP5 interactions reverse inflammatory and neuropathic pain
por: Gadotti, Vinicius M, et al.
Publicado: (2015)