CD47 cross-dressing by extracellular vesicles expressing CD47 inhibits phagocytosis without transmitting cell death signals

Transgenic CD47 overexpression is an encouraging approach to ameliorating xenograft rejection and alloresponses to pluripotent stem cells, and the efficacy correlates with the level of CD47 expression. However, CD47, upon ligation, also transmits signals leading to cell dysfunction or death, raising...

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Detalles Bibliográficos
Autores principales: Li, Yang, Wu, Yan, Federzoni, Elena A, Wang, Xiaodan, Dharmawan, Andre, Hu, Xiaoyi, Wang, Hui, Hawley, Robert J, Stevens, Sean, Sykes, Megan, Yang, Yong-Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714967/
https://www.ncbi.nlm.nih.gov/pubmed/36454036
http://dx.doi.org/10.7554/eLife.73677

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714967/
https://www.ncbi.nlm.nih.gov/pubmed/36454036
http://dx.doi.org/10.7554/eLife.73677

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