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Rational engineering of adeno‐associated virus capsid enhances human hepatocyte tropism and reduces immunogenicity

OBJECTIVES: Gene therapy based on recombinant adeno‐associated viral (rAAV) vectors has been proved to be clinically effective for genetic diseases. However, there are still some limitations, including possible safety concerns for high dose delivery and a decreasing number of target patients caused...

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Detalles Bibliográficos
Autores principales:	Han, Jiabao, Zhu, Liyu, Zhang, Jingwen, Guo, Lu, Sun, Xuehan, Huang, Cheng, Xu, Kai, Zhang, Ying, Li, Wei, Zhou, Qi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715358/ https://www.ncbi.nlm.nih.gov/pubmed/36135100 http://dx.doi.org/10.1111/cpr.13339

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